Propylhexedrine (free base)

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MedKoo CAT#: 412847

CAS#: 101-40-6 (free base)

Description: Propylhexedrine (free base) is an alpha-adrenergic stimulant used extensively in nasal decongestant inhalers.

Chemical Structure

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Propylhexedrine (free base)
CAS# 101-40-6 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 412847
Name: Propylhexedrine (free base)
CAS#: 101-40-6 (free base)
Chemical Formula: C10H21N
Exact Mass: 155.17
Molecular Weight: 155.290
Elemental Analysis: C, 77.35; H, 13.63; N, 9.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1007-33-6 (HCl)   101-40-6 (free base)  

Synonym: Propylhexedrine; NSC32410; NSC-32410; NSC 32410

IUPAC/Chemical Name: 1-cyclohexyl-N-methylpropan-2-amine

InChi Key: JCRIVQIOJSSCQD-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3

SMILES Code: CNC(CC1CCCCC1)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 155.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Teja N, Dodge CP, Stanciu CN. Abuse, Toxicology and the Resurgence of Propylhexedrine: A Case Report and Review of Literature. Cureus. 2020 Oct 9;12(10):e10868. doi: 10.7759/cureus.10868. PMID: 33178521; PMCID: PMC7652022.

2: Wesson DR. Propylhexdrine. Drug Alcohol Depend. 1986 Jun;17(2-3):273-8. doi: 10.1016/0376-8716(86)90013-x. PMID: 2874970.

3: Croft CH, Firth BG, Hillis LD. Propylhexedrine-induced left ventricular dysfunction. Ann Intern Med. 1982 Oct;97(4):560-1. doi: 10.7326/0003-4819-97-4-560. PMID: 6127046.

4: Iven H, Feldbusch E. Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(2):153-9. doi: 10.1007/BF00497022. PMID: 6139756.

5: Anderson ED. Propylhexedrine (Benzedrex) psychosis. N Z Med J. 1970 May;71(456):302. PMID: 5270979.

6: Riddick L, Reisch R. Oral overdose of propylhexedrine. J Forensic Sci. 1981 Oct;26(4):834-9. PMID: 6117600.

7: White L, DiMaio VJ. Intravenous propylhexedrine and sudden death. N Engl J Med. 1977 Nov 10;297(19):1071. doi: 10.1056/nejm197711102971920. PMID: 20578.

8: Hamilton LH. Nasal decongestant effect of propylhexedrine. Ann Otol Rhinol Laryngol. 1982 Jan-Feb;91(1 Pt 1):106-11. doi: 10.1177/000348948209100124. PMID: 6176171.

9: Appel W, Sprengard D. Zur Pharmakokinetik von Propylhexedrine [Pharmacokinetics of propylhexedrine]. Arzneimittelforschung. 1971 Jun;21(6):894-9. German. PMID: 5109288.

10: Holler JM, Vorce SP, McDonough-Bender PC, Magluilo J Jr, Solomon CJ, Levine B. A drug toxicity death involving propylhexedrine and mitragynine. J Anal Toxicol. 2011 Jan;35(1):54-9. doi: 10.1093/anatox/35.1.54. PMID: 21219704.