Propylhexedrine HCl | CAS#1007-33-6

Propylhexedrine HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318591

CAS#: 1007-33-6 (HCl)

Description: Propylhexedrine is an α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor. It is the active ingredient in some over-the-counter nasal decongestants, typically by intravenous or oral delivery of the nasal decongestant.

Chemical Structure

Propylhexedrine HCl

CAS# 1007-33-6 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 318591
Name: Propylhexedrine HCl
CAS#: 1007-33-6 (HCl)
Chemical Formula: C10H22ClN
Exact Mass: 0.00
Molecular Weight: 191.740
Elemental Analysis: C, 62.64; H, 11.56; Cl, 18.49; N, 7.30

Price and Availability

Size	Price	Availability
5mg	USD 285	2 Weeks
10mg	USD 450	2 Weeks
50mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1007-33-6 (HCl) 101-40-6 (free base)

Synonym: Propylhexedrine Hydrochloride; Eventin HCl; Benzedrex; Eggobesin; Benzedrex HCl; propylhexedrine HCl; NSC 170998; NSC 27110;

IUPAC/Chemical Name: 1-cyclohexyl-N-methylpropan-2-amine;hydrochloride

InChi Key: WLEGHNSHAIHZPS-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H21N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h9-11H,3-8H2,1-2H3;1H

SMILES Code: CC(CC1CCCCC1)NC.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 191.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fernandez Julia P, Francis EM. Propylhexedrine: a vintage drug of abuse,
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5: Croft CH, Firth BG, Hillis LD. Propylhexedrine-induced left ventricular
dysfunction. Ann Intern Med. 1982 Oct;97(4):560-1. PubMed PMID: 6127046.

6: Liggett SB. Propylhexedrine Intoxication: Clinical Presentation and
Pharmacology. South Med J. 1982 Feb;75(2):250-1. PubMed PMID: 6120574.

7: White L, DiMaio VJ. Intravenous propylhexedrine and sudden death. N Engl J
Med. 1977 Nov 10;297(19):1071. PubMed PMID: 20578.

8: DiMaio VJ, Garriott JC. Intravenous abuse of propylhexedrine. J Forensic Sci.
1977 Jan;22(1):152-8. PubMed PMID: 45496.

9: Sturner WQ, Spruill FG, Garriott JC. Two propylhexedrine-associated
fatalities: Benzedrine revisited. J Forensic Sci. 1974 Jul;19(3):572-4. PubMed
PMID: 4137337.

10: Appel W, Sprengard D. [Pharmacokinetics of propylhexedrine].
Arzneimittelforschung. 1971 Jun;21(6):894-9. German. PubMed PMID: 5109288.

11: Anderson ED. Propylhexedrine (Benzedrex) psychosis. N Z Med J. 1970
May;71(456):302. PubMed PMID: 5270979.

12: Dick RW, Mitchell CL. A comparison of the anticonvulsant properties of
l-propylhexedrine, phenobarbital and a salt-like complex of l-propylhexedrine and
phenobarbital in mice and rats. Arch Int Pharmacodyn Ther. 1967
Dec;170(2):333-42. PubMed PMID: 6076581.

13: POLSTER H. [ON POISONING WITH THE APPETITE DEPRESSANT PROPYLHEXEDRINE,
"OBESIN" IN A 3-YEAR-OLD CHILD]. Arch Toxikol. 1965 Feb 10;20:271-3. German.
PubMed PMID: 14272412.

14: Smith DE, Wesson DR, Sees KL, Morgan JP. An epidemiological and clinical
analysis of propylhexedrine abuse in the United States. J Psychoactive Drugs.
1988 Oct-Dec;20(4):441-2. PubMed PMID: 2907528.

15: Covey DC, Nossaman BD, Albright JA. Ischemic injury of the hand from
intra-arterial propylhexedrine injection. J Hand Surg Am. 1988 Jan;13(1):58-61.
PubMed PMID: 2895132.

16: Fornazzari L, Carlen PL, Kapur BM. Intravenous abuse of propylhexedrine
(Benzedrex) and the risk of brainstem dysfunction in young adults. Can J Neurol
Sci. 1986 Nov;13(4):337-9. PubMed PMID: 2877725.

17: Perucca E, Grimaldi R, Ruberto G, Gelmi C, Trimarchi F, Crema A. Comparative
kinetics of phenobarbital after administration of the acid and the
propylhexedrine salt (barbexaclone). Eur J Clin Pharmacol. 1986;29(6):729-30.
PubMed PMID: 3709618.

18: Mancusi-Ungaro HR Jr, Decker WJ, Forshan VR, Blackwell SJ, Lewis SR. Tissue
injuries associated with parenteral propylhexedrine abuse. J Toxicol Clin
Toxicol. 1983-1984;21(3):359-72. PubMed PMID: 6144800.

19: Hamilton LH. Nasal decongestant effect of propylhexedrine. Ann Otol Rhinol
Laryngol. 1982 Jan-Feb;91(1 Pt 1):106-11. PubMed PMID: 6176171.

20: Riddick L, Reisch R. Oral overdose of propylhexedrine. J Forensic Sci. 1981
Oct;26(4):834-9. PubMed PMID: 6117600.

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