ZXH-3-26 HCl

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MedKoo CAT#: 462565

CAS#: ZXH-3-26 HCl

Description: ZXH-3-26 is a selective PROTAC BRD4 degrader.

Chemical Structure

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ZXH-3-26 HCl
CAS# ZXH-3-26 HCl
Instruction

Theoretical Analysis

MedKoo Cat#: 462565
Name: ZXH-3-26 HCl
CAS#: ZXH-3-26 HCl
Chemical Formula: C38H38Cl2N8O7S
Exact Mass: 784.22
Molecular Weight: 821.731
Elemental Analysis: C, 55.54; H, 4.66; Cl, 8.63; N, 13.64; O, 13.63; S, 3.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 2243076-67-5 (free base)   2307475-86-9 (TFA)   ZXH-3-26 HCl    

Synonym: ZXH-3-26; ZXH3-26; ZXH 3-26; ZXH-326; ZXH326; ZXH 326; ZXH-3-26 HCl; ZXH-3-26 Hydrochloride.

IUPAC/Chemical Name: methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate hydrochloride

InChi Key: PPIOEVXQEWNZJE-XZTCEYQHSA-N

InChi Code: InChI=1S/C38H37ClN8O7S.ClH/c1-19-29-31(21-10-12-22(39)13-11-21)42-25(18-28(49)54-3)33-45-44-20(2)46(33)38(29)55-32(19)35(51)41-17-6-4-5-16-40-24-9-7-8-23-30(24)37(53)47(36(23)52)26-14-15-27(48)43-34(26)50;/h7-13,25-26,40H,4-6,14-18H2,1-3H3,(H,41,51)(H,43,48,50);1H/t25-,26?;/m0./s1

SMILES Code: O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 821.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nowak RP, DeAngelo SL, Buckley D, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018;14(7):706-714. doi:10.1038/s41589-018-0055-y