ZXH-3-26
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MedKoo CAT#: 564678

CAS#: 2243076-67-5 (free base)

Description: ZXH-3-26 is a selective degrader of BRD4.


Chemical Structure

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ZXH-3-26
CAS# 2243076-67-5 (free base)

Theoretical Analysis

MedKoo Cat#: 564678
Name: ZXH-3-26
CAS#: 2243076-67-5 (free base)
Chemical Formula: C39H39ClN8O7S
Exact Mass: 798.24
Molecular Weight: 799.300
Elemental Analysis: C, 58.60; H, 4.92; Cl, 4.44; N, 14.02; O, 14.01; S, 4.01

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Related CAS #: 2243076-67-5 (free base)   2307475-86-9 (TFA)   ZXH-3-26 HCl    

Synonym: ZXH326; ZXH 326; ZXH-326; ZXH 3 26; ZXH-326; ZXH-3-26;

IUPAC/Chemical Name: Methyl 2-((6S)-4-(4-chlorophenyl)-2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

InChi Key: KLLGWPDWPSUTCL-QBHOUYDASA-N

InChi Code: InChI=1S/C39H39ClN8O7S/c1-20-30-32(22-11-13-23(40)14-12-22)43-26(19-29(50)55-3)34-46-45-21(2)47(34)39(30)56-33(20)36(52)42-18-7-5-4-6-17-41-25-10-8-9-24-31(25)38(54)48(37(24)53)27-15-16-28(49)44-35(27)51/h8-14,26-27,41H,4-7,15-19H2,1-3H3,(H,42,52)(H,44,49,51)/t26-,27?/m0/s1

SMILES Code: O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 799.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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