Atorvastatin | CAS#134523-00-5 | Hydroxymethylglutaryl-CoA reductase inhibitor.

Atorvastatin
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598955

CAS#: 134523-00-5 (free acid)

Description: Atorvastatin is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia.

Chemical Structure

Atorvastatin

CAS# 134523-00-5 (free acid)

Instruction

Theoretical Analysis

MedKoo Cat#: 598955
Name: Atorvastatin
CAS#: 134523-00-5 (free acid)
Chemical Formula: C33H35FN2O5
Exact Mass: 558.25
Molecular Weight: 558.650
Elemental Analysis: C, 70.95; H, 6.32; F, 3.40; N, 5.01; O, 14.32

Price and Availability

Size	Price	Availability
100mg	USD 250	2 Weeks
250mg	USD 450	2 Weeks
500mg	USD 750	2 Weeks
1g	USD 1250	2 Weeks
2g	USD 2050	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Atorvastatin; Lipilou; Tozalip; Torvast; Cardyl;

IUPAC/Chemical Name: (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid

InChi Key: XUKUURHRXDUEBC-KAYWLYCHSA-N

InChi Code: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1

SMILES Code: O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C1C(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 558.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Delgado-Montero A, Zamorano JL. Atorvastatin calcium plus amlodipine for the treatment of hypertension. Expert Opin Pharmacother. 2012 Dec;13(18):2673-85. doi: 10.1517/14656566.2012.742064. Review. PubMed PMID: 23140185.

2: Goriacko P, Andersen M, Fazylov R, Plakogiannis R. What Is the Appropriate Duration of High-Dose Atorvastatin Therapy Post-Acute Coronary Syndrome? J Pharm Pract. 2015 Dec;28(6):555-60. Review. PubMed PMID: 25107416.

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6: Qian C, Wei B, Ding J, Wu H, Cai X, Li B, Wang Y. Meta-analysis comparing the effects of rosuvastatin versus atorvastatin on regression of coronary atherosclerotic plaques. Am J Cardiol. 2015 Nov 15;116(10):1521-6. doi: 10.1016/j.amjcard.2015.08.010. Review. PubMed PMID: 26385518.

7: Blank R. A single-pill combination of amlodipine besylate and atorvastatin calcium. Drugs Today (Barc). 2006 Mar;42(3):157-75. Review. PubMed PMID: 16628258.

8: Adams SP, Tsang M, Wright JM. Lipid-lowering efficacy of atorvastatin. Cochrane Database Syst Rev. 2015 Mar 12;(3):CD008226. doi: 10.1002/14651858.CD008226.pub3. Review. PubMed PMID: 25760954.

9: Ye YC, Zhao XL, Zhang SY. Use of atorvastatin in lipid disorders and cardiovascular disease in Chinese patients. Chin Med J (Engl). 2015 Jan 20;128(2):259-66. doi: 10.4103/0366-6999.149226. Review. PubMed PMID: 25591572; PubMed Central PMCID: PMC4837848.

10: Dai G, Xu Q, Luo R, Gao J, Chen H, Deng Y, Li Y, Wang Y, Yuan W, Wu X. Atorvastatin treatment improves effects of implanted mesenchymal stem cells: meta-analysis of animal models with acute myocardial infarction. BMC Cardiovasc Disord. 2015 Dec 14;15:170. doi: 10.1186/s12872-015-0162-6. Review. PubMed PMID: 26667804; PubMed Central PMCID: PMC4678482.

11: Takagi H, Niwa M, Mizuno Y, Yamamoto H, Goto SN, Umemoto T. Effects of rosuvastatin versus atorvastatin on small dense low-density lipoprotein: a meta-analysis of randomized trials. Heart Vessels. 2014 May;29(3):287-99. doi: 10.1007/s00380-013-0358-6. Review. PubMed PMID: 23644555.

12: Takagi H, Umemoto T; ALICE (All-Literature Investigation of Cardiovascular Evidence) Group.. A meta-analysis of randomized head-to-head trials for effects of rosuvastatin versus atorvastatin on apolipoprotein profiles. Am J Cardiol. 2014 Jan 15;113(2):292-301. doi: 10.1016/j.amjcard.2013.08.043. Review. PubMed PMID: 24230979.

13: Yang Q, Qi X, Li Y. The preventive effect of atorvastatin on atrial fibrillation: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2014 Aug 13;14:99. doi: 10.1186/1471-2261-14-99. Review. PubMed PMID: 25117689; PubMed Central PMCID: PMC4135360.

14: Simoens S, Sinnaeve PR. Generic atorvastatin, the Belgian statin market and the cost-effectiveness of statin therapy. Cardiovasc Drugs Ther. 2013 Feb;27(1):49-60. doi: 10.1007/s10557-012-6432-y. Review. PubMed PMID: 23242669.

15: Adams SP, Tsang M, Wright JM. Lipid lowering efficacy of atorvastatin. Cochrane Database Syst Rev. 2012 Dec 12;12:CD008226. doi: 10.1002/14651858.CD008226.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;3:CD008226. PubMed PMID: 23235655.

16: Violi F, Carnevale R, Pastori D, Pignatelli P. Antioxidant and antiplatelet effects of atorvastatin by Nox2 inhibition. Trends Cardiovasc Med. 2014 May;24(4):142-8. doi: 10.1016/j.tcm.2013.09.006. Review. PubMed PMID: 24263084.

17: Poolsup N, Suksomboon N, Wongyaowarat K, Rungkanchananon B, Niyomrat P, Kongsuwan S. Meta-analysis of the comparative efficacy and safety of pitavastatin and atorvastatin in patients with dyslipidaemia. J Clin Pharm Ther. 2012 Apr;37(2):166-72. doi: 10.1111/j.1365-2710.2011.01274.x. Review. PubMed PMID: 21585411.

18: Liu M, Alafris A, Longo AJ, Cohen H. Irreversible atorvastatin-associated hearing loss. Pharmacotherapy. 2012 Feb;32(2):e27-34. doi: 10.1002/PHAR.1040. Review. PubMed PMID: 22392429.

19: McKenney JM. Combination treatment with atorvastatin plus niacin provides effective control of complex dyslipidemias: a literature review. Postgrad Med. 2012 Jan;124(1):7-20. doi: 10.3810/pgm.2012.01.2513. Review. PubMed PMID: 22314110.

20: DiNicolantonio JJ, Lavie CJ, Serebruany VL, O'Keefe JH. Statin wars: the heavyweight match--atorvastatin versus rosuvastatin for the treatment of atherosclerosis, heart failure, and chronic kidney disease. Postgrad Med. 2013 Jan;125(1):7-16. doi: 10.3810/pgm.2013.01.2620. Review. PubMed PMID: 23391667.

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