Atorvastatin calcium trihydrate
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MedKoo CAT#: 317257

CAS#: 344423-98-9 (calcium trihydrate)

Description: Atorvastatin is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia.


Chemical Structure

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Atorvastatin calcium trihydrate
CAS# 344423-98-9 (calcium trihydrate)

Theoretical Analysis

MedKoo Cat#: 317257
Name: Atorvastatin calcium trihydrate
CAS#: 344423-98-9 (calcium trihydrate)
Chemical Formula: C66H74CaF2N4O13
Exact Mass:
Molecular Weight: 1209.38757
Elemental Analysis: C, 65.55; H, 6.17; Ca, 3.31; F, 3.14; N, 4.63; O, 17.20

Size Price Shipping out time Quantity
2g USD 150 Same Day
5g USD 250 Same Day
10g USD 450 Same Day
100g USD 1650 Same Day
500g USD 3650 Same Day
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Pricing updated 2021-03-05. Prices are subject to change without notice.

Atorvastatin calcium trihydrate, purity > 98%, is in stock.The same day shipping out after order is received.

Related CAS #: 134523-03-8 (calcium)   344423-98-9 (calcium trihydrate)   134523-00-5 (free acid)   134523-01-6 (sodium)   874114-41-7 (magnesium)    

Synonym: CI-981; CI 981; CI981; Atorvastatin; atorvastatin calcium trihydrate; atorvastatin, calcium salt; Brand name: Lipitor; liptonorm

IUPAC/Chemical Name: calcium (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate trihydrate

InChi Key: SHZPNDRIDUBNMH-NIJVSVLQSA-L

InChi Code: InChI=1S/2C33H35FN2O5.Ca.3H2O/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;3*1H2/q;;+2;;;/p-2/t2*26-,27-;;;;/m11..../s1

SMILES Code: O=C(NC1=CC=CC=C1)C2=C(N(C(C3=CC=C(C=C3)F)=C2C4=CC=CC=C4)CC[C@H](C[C@H](CC([O-])=O)O)O)C(C)C.O=C(NC5=CC=CC=C5)C6=C(N(C(C7=CC=C(C=C7)F)=C6C8=CC=CC=C8)CC[C@H](C[C@H](CC([O-])=O)O)O)C(C)C.[H]O[H].[H]O[H].[H]O[H].[Ca+2]

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1209.38757 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Delgado-Montero A, Zamorano JL. Atorvastatin calcium plus amlodipine for the treatment of hypertension. Expert Opin Pharmacother. 2012 Dec;13(18):2673-85. doi: 10.1517/14656566.2012.742064. Review. PubMed PMID: 23140185.

2: Goriacko P, Andersen M, Fazylov R, Plakogiannis R. What Is the Appropriate Duration of High-Dose Atorvastatin Therapy Post-Acute Coronary Syndrome? J Pharm Pract. 2015 Dec;28(6):555-60. Review. PubMed PMID: 25107416.

3: Karlson BW, Palmer MK, Nicholls SJ, Lundman P, Barter PJ. Doses of rosuvastatin, atorvastatin and simvastatin that induce equal reductions in LDL-C and non-HDL-C: Results from the VOYAGER meta-analysis. Eur J Prev Cardiol. 2016 May;23(7):744-7. doi: 10.1177/2047487315598710. Review. PubMed PMID: 26246463.

4: Li H, Wang C, Zhang S, Sun S, Li R, Zou M, Cheng G. Safety Profile of Atorvastatin 80 mg: A Meta-Analysis of 17 Randomized Controlled Trials in 21,910 Participants. Drug Saf. 2016 May;39(5):409-19. doi: 10.1007/s40264-016-0394-0. Review. PubMed PMID: 26860922.

5: Fang N, Han W, Gong D, Zou Chen, Fan Y. Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes: A Meta-Analysis. Medicine (Baltimore). 2015 Nov;94(44):e1920. doi: 10.1097/MD.0000000000001920. Review. PubMed PMID: 26554793; PubMed Central PMCID: PMC4915894.

6: Qian C, Wei B, Ding J, Wu H, Cai X, Li B, Wang Y. Meta-analysis comparing the effects of rosuvastatin versus atorvastatin on regression of coronary atherosclerotic plaques. Am J Cardiol. 2015 Nov 15;116(10):1521-6. doi: 10.1016/j.amjcard.2015.08.010. Review. PubMed PMID: 26385518.

7: Blank R. A single-pill combination of amlodipine besylate and atorvastatin calcium. Drugs Today (Barc). 2006 Mar;42(3):157-75. Review. PubMed PMID: 16628258.

8: Adams SP, Tsang M, Wright JM. Lipid-lowering efficacy of atorvastatin. Cochrane Database Syst Rev. 2015 Mar 12;(3):CD008226. doi: 10.1002/14651858.CD008226.pub3. Review. PubMed PMID: 25760954.

9: Ye YC, Zhao XL, Zhang SY. Use of atorvastatin in lipid disorders and cardiovascular disease in Chinese patients. Chin Med J (Engl). 2015 Jan 20;128(2):259-66. doi: 10.4103/0366-6999.149226. Review. PubMed PMID: 25591572; PubMed Central PMCID: PMC4837848.

10: Dai G, Xu Q, Luo R, Gao J, Chen H, Deng Y, Li Y, Wang Y, Yuan W, Wu X. Atorvastatin treatment improves effects of implanted mesenchymal stem cells: meta-analysis of animal models with acute myocardial infarction. BMC Cardiovasc Disord. 2015 Dec 14;15:170. doi: 10.1186/s12872-015-0162-6. Review. PubMed PMID: 26667804; PubMed Central PMCID: PMC4678482.

11: Takagi H, Niwa M, Mizuno Y, Yamamoto H, Goto SN, Umemoto T. Effects of rosuvastatin versus atorvastatin on small dense low-density lipoprotein: a meta-analysis of randomized trials. Heart Vessels. 2014 May;29(3):287-99. doi: 10.1007/s00380-013-0358-6. Review. PubMed PMID: 23644555.

12: Takagi H, Umemoto T; ALICE (All-Literature Investigation of Cardiovascular Evidence) Group.. A meta-analysis of randomized head-to-head trials for effects of rosuvastatin versus atorvastatin on apolipoprotein profiles. Am J Cardiol. 2014 Jan 15;113(2):292-301. doi: 10.1016/j.amjcard.2013.08.043. Review. PubMed PMID: 24230979.

13: Yang Q, Qi X, Li Y. The preventive effect of atorvastatin on atrial fibrillation: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2014 Aug 13;14:99. doi: 10.1186/1471-2261-14-99. Review. PubMed PMID: 25117689; PubMed Central PMCID: PMC4135360.

14: Simoens S, Sinnaeve PR. Generic atorvastatin, the Belgian statin market and the cost-effectiveness of statin therapy. Cardiovasc Drugs Ther. 2013 Feb;27(1):49-60. doi: 10.1007/s10557-012-6432-y. Review. PubMed PMID: 23242669.

15: Adams SP, Tsang M, Wright JM. Lipid lowering efficacy of atorvastatin. Cochrane Database Syst Rev. 2012 Dec 12;12:CD008226. doi: 10.1002/14651858.CD008226.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;3:CD008226. PubMed PMID: 23235655.

16: Violi F, Carnevale R, Pastori D, Pignatelli P. Antioxidant and antiplatelet effects of atorvastatin by Nox2 inhibition. Trends Cardiovasc Med. 2014 May;24(4):142-8. doi: 10.1016/j.tcm.2013.09.006. Review. PubMed PMID: 24263084.

17: Poolsup N, Suksomboon N, Wongyaowarat K, Rungkanchananon B, Niyomrat P, Kongsuwan S. Meta-analysis of the comparative efficacy and safety of pitavastatin and atorvastatin in patients with dyslipidaemia. J Clin Pharm Ther. 2012 Apr;37(2):166-72. doi: 10.1111/j.1365-2710.2011.01274.x. Review. PubMed PMID: 21585411.

18: Liu M, Alafris A, Longo AJ, Cohen H. Irreversible atorvastatin-associated hearing loss. Pharmacotherapy. 2012 Feb;32(2):e27-34. doi: 10.1002/PHAR.1040. Review. PubMed PMID: 22392429.

19: McKenney JM. Combination treatment with atorvastatin plus niacin provides effective control of complex dyslipidemias: a literature review. Postgrad Med. 2012 Jan;124(1):7-20. doi: 10.3810/pgm.2012.01.2513. Review. PubMed PMID: 22314110.

20: DiNicolantonio JJ, Lavie CJ, Serebruany VL, O'Keefe JH. Statin wars: the heavyweight match--atorvastatin versus rosuvastatin for the treatment of atherosclerosis, heart failure, and chronic kidney disease. Postgrad Med. 2013 Jan;125(1):7-16. doi: 10.3810/pgm.2013.01.2620. Review. PubMed PMID: 23391667.