PRX-03140 potassium

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MedKoo CAT#: 529009

CAS#: 869493-26-5 (potassium)

Description: VRX 03011, also known as NTC-942 and PRX-03140, is a 5-HT4 partial agonist potentially for the treatment of Alzheimer's disease.

Chemical Structure

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PRX-03140 potassium
CAS# 869493-26-5 (potassium)
Instruction

Theoretical Analysis

MedKoo Cat#: 529009
Name: PRX-03140 potassium
CAS#: 869493-26-5 (potassium)
Chemical Formula: C19H26KN3O3S
Exact Mass: 0.00
Molecular Weight: 415.590
Elemental Analysis: C, 54.91; H, 6.31; K, 9.41; N, 10.11; O, 11.55; S, 7.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 869493-21-0 (free)   869493-26-5 (potassium)    

Synonym: NTC-942; NTC942; NTC 942; PRX-03140; PRX-3140; PRX03140; PRX3140; PRX 03140; PRX 3140; VRX 03011; VRX 03011; VRX-03011

IUPAC/Chemical Name: potassium 7-isopropyl-6-oxo-5-((3-(piperidin-1-yl)propyl)carbamoyl)-6,7-dihydrothieno[2,3-b]pyridin-4-olate

InChi Key: JWRDEPYIIBDWDI-UHFFFAOYSA-M

InChi Code: InChI=1S/C19H27N3O3S.K/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21;/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24);/q;+1/p-1

SMILES Code: O=C(C1=C([O-])C(C=CS2)=C2N(C(C)C)C1=O)NCCCN3CCCCC3.[K+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 415.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mohler EG, Shacham S, Noiman S, Lezoualc'h F, Robert S, Gastineau M, Rutkowski J, Marantz Y, Dumuis A, Bockaert J, Gold PE, Ragozzino ME. VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux. Neuropharmacology. 2007 Sep;53(4):563-73. PubMed PMID: 17692343.

2: Johnson DE, Drummond E, Grimwood S, Sawant-Basak A, Miller E, Tseng E, McDowell LL, Vanase-Frawley MA, Fisher KE, Rubitski DM, Stutzman-Engwall KJ, Nelson RT, Horner WE, Gorczyca RR, Hajos M, Siok CJ. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3):681-91. doi: 10.1124/jpet.112.192351. PubMed PMID: 22408061.

3: Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment. Neuropharmacology. 2011 Jul-Aug;61(1-2):69-79. doi: 10.1016/j.neuropharm.2011.02.026. PubMed PMID: 21392515.