WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 529009
CAS#: 869493-26-5 (potassium)
Description: VRX 03011, also known as NTC-942 and PRX-03140, is a 5-HT4 partial agonist potentially for the treatment of Alzheimer's disease.
MedKoo Cat#: 529009
Name: PRX-03140 potassium
CAS#: 869493-26-5 (potassium)
Chemical Formula: C19H26KN3O3S
Exact Mass:
Molecular Weight: 415.59
Elemental Analysis: C, 54.91; H, 6.31; K, 9.41; N, 10.11; O, 11.55; S, 7.71
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 869493-21-0 (free) 869493-26-5 (potassium)
Synonym: NTC-942; NTC942; NTC 942; PRX-03140; PRX-3140; PRX03140; PRX3140; PRX 03140; PRX 3140; VRX 03011; VRX 03011; VRX-03011
IUPAC/Chemical Name: potassium 7-isopropyl-6-oxo-5-((3-(piperidin-1-yl)propyl)carbamoyl)-6,7-dihydrothieno[2,3-b]pyridin-4-olate
InChi Key: JWRDEPYIIBDWDI-UHFFFAOYSA-M
InChi Code: InChI=1S/C19H27N3O3S.K/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21;/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24);/q;+1/p-1
SMILES Code: O=C(C1=C([O-])C(C=CS2)=C2N(C(C)C)C1=O)NCCCN3CCCCC3.[K+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 415.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mohler EG, Shacham S, Noiman S, Lezoualc'h F, Robert S, Gastineau M, Rutkowski J, Marantz Y, Dumuis A, Bockaert J, Gold PE, Ragozzino ME. VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux. Neuropharmacology. 2007 Sep;53(4):563-73. PubMed PMID: 17692343.
2: Johnson DE, Drummond E, Grimwood S, Sawant-Basak A, Miller E, Tseng E, McDowell LL, Vanase-Frawley MA, Fisher KE, Rubitski DM, Stutzman-Engwall KJ, Nelson RT, Horner WE, Gorczyca RR, Hajos M, Siok CJ. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3):681-91. doi: 10.1124/jpet.112.192351. PubMed PMID: 22408061.
3: Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment. Neuropharmacology. 2011 Jul-Aug;61(1-2):69-79. doi: 10.1016/j.neuropharm.2011.02.026. PubMed PMID: 21392515.
