PRX-03140

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MedKoo CAT#: 562914

CAS#: 869493-21-0 (free)

Description: VRX 03011, also known as NTC-942 and PRX-03140, is a 5-HT4 partial agonist potentially for the treatment of Alzheimer's disease.


Chemical Structure

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PRX-03140
CAS# 869493-21-0 (free)

Theoretical Analysis

MedKoo Cat#: 562914
Name: PRX-03140
CAS#: 869493-21-0 (free)
Chemical Formula: C19H27N3O3S
Exact Mass: 377.18
Molecular Weight: 377.500
Elemental Analysis: C, 60.45; H, 7.21; N, 11.13; O, 12.71; S, 8.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 869493-21-0 (free)   869493-26-5 (potassium)    

Synonym: NTC-942; NTC942; NTC 942; PRX-03140; PRX-3140; PRX03140; PRX3140; PRX 03140; PRX 3140; VRX 03011; VRX 03011; VRX-03011

IUPAC/Chemical Name: 4-hydroxy-7-isopropyl-6-oxo-N-(3-(piperidin-1-yl)propyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

InChi Key: SCHKZZSVELPJKU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24)

SMILES Code: CC(C)N1C2=C(C=CS2)C(O)=C(C(NCCCN3CCCCC3)=O)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 377.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ramakrishna Nirogi, Abdul Rasheed Mohammed, Anil K. Shinde, Shankar Reddy Gagginapally, Durga Malleshwari Kancharla, Vanaja Reddy Middekadi, Narsimha Bogaraju, Srinivasa Rao Ravella, Pooja Singh, Sumit Raosaheb Birangal, Ramkumar Subramanian, Raghava Choudary Palacharla, Vijay Benade, Nageswararao Muddana, and Pradeep Jayarajan. Synthesis, Structure–Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists. Publication Date (Web): May 15, 2018 (Article)
DOI: 10.1021/acs.jmedchem.8b00457