WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562914
CAS#: 869493-21-0 (free)
Description: VRX 03011, also known as NTC-942 and PRX-03140, is a 5-HT4 partial agonist potentially for the treatment of Alzheimer's disease.
MedKoo Cat#: 562914
Name: PRX-03140
CAS#: 869493-21-0 (free)
Chemical Formula: C19H27N3O3S
Exact Mass: 377.1773
Molecular Weight: 377.5
Elemental Analysis: C, 60.45; H, 7.21; N, 11.13; O, 12.71; S, 8.49
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Related CAS #: 869493-21-0 (free) 869493-26-5 (potassium)
Synonym: NTC-942; NTC942; NTC 942; PRX-03140; PRX-3140; PRX03140; PRX3140; PRX 03140; PRX 3140; VRX 03011; VRX 03011; VRX-03011
IUPAC/Chemical Name: 4-hydroxy-7-isopropyl-6-oxo-N-(3-(piperidin-1-yl)propyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carboxamide
InChi Key: SCHKZZSVELPJKU-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24)
SMILES Code: CC(C)N1C2=C(C=CS2)C(O)=C(C(NCCCN3CCCCC3)=O)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 377.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Ramakrishna Nirogi, Abdul Rasheed Mohammed, Anil K. Shinde, Shankar Reddy Gagginapally, Durga Malleshwari Kancharla, Vanaja Reddy Middekadi, Narsimha Bogaraju, Srinivasa Rao Ravella, Pooja Singh, Sumit Raosaheb Birangal, Ramkumar Subramanian, Raghava Choudary Palacharla, Vijay Benade, Nageswararao Muddana, and Pradeep Jayarajan. Synthesis, Structure–Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists. Publication Date (Web): May 15, 2018 (Article)
DOI: 10.1021/acs.jmedchem.8b00457
