Fosfluconazole | CAS#194798-83-9

Fosfluconazole
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525075

CAS#: 194798-83-9 (free acid)

Description: Fosfluconazole is water-soluble phosphate prodrug of fluconazole. Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

Chemical Structure

Fosfluconazole

CAS# 194798-83-9 (free acid)

Instruction

Theoretical Analysis

MedKoo Cat#: 525075
Name: Fosfluconazole
CAS#: 194798-83-9 (free acid)
Chemical Formula: C13H13F2N6O4P
Exact Mass: 386.07
Molecular Weight: 386.250
Elemental Analysis: C, 40.42; H, 3.39; F, 9.84; N, 21.76; O, 16.57; P, 8.02

Price and Availability

Size	Price	Availability
5mg	USD 295	2 Weeks
10mg	USD 550	2 Weeks
25mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 194798-85-1 (sodium) 194798-83-9 (free acid)

Synonym: Fosfluconazole; Fosfluconazole, Procif; UK 292663; UK-292,663.

IUPAC/Chemical Name: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-((1H-1,2,4-triazol-1-yl)methyl)ethyl dihydrogen phosphate

InChi Key: GHJWNRRCRIGGIO-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)

SMILES Code: c1cc(c(cc1F)F)C(Cn2cncn2)(Cn3cncn3)OP(=O)(O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 386.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Hagiya H, Kajioka H. Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of fosfluconazole and micafungin. Intern Med. 2013;52(18):2139-43. PubMed PMID: 24042529.

2: Aoyama T, Hirata K, Hirata R, Yamazaki H, Yamamoto Y, Hayashi H, Matsumoto Y. Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients. J Clin Pharm Ther. 2012 Jun;37(3):356-63. doi: 10.1111/j.1365-2710.2011.01297.x. Epub 2011 Aug 24. PubMed PMID: 21883330.

3: Sawada A, Sakata N, Higuchi B, Takeshita Y, Ishihara T, Sakata A, Kouroki M, Kondo O, Koyama M, Hirano S, Yasui M, Inoue M, Yoshioka A, Kawa K. [Comparison of micafungin and fosfluconazole as prophylaxis for invasive fungal infection during neutropenia in children undergoing chemotherapy and hematopoietic stem cell transplantation]. Rinsho Ketsueki. 2009 Dec;50(12):1692-9. Japanese. PubMed PMID: 20068276.

4: Takahashi D, Nakamura T, Shigematsu R, Matsui M, Araki S, Kubo K, Sato H, Shirahata A. Fosfluconazole for antifungal prophylaxis in very low birth weight infants. Int J Pediatr. 2009;2009:274768. doi: 10.1155/2009/274768. Epub 2009 Apr 23. PubMed PMID: 19946419; PubMed Central PMCID: PMC2778452.

5: Aoyama T, Ogata K, Shimizu M, Hatta S, Masuhara K, Shima Y, Kimura K, Matsumoto Y. Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats. Drug Metab Pharmacokinet. 2005 Dec;20(6):485-90. PubMed PMID: 16415533.

6: Sobue S, Tan K, Haug-Pihale G. The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. Br J Clin Pharmacol. 2005 Feb;59(2):160-6. PubMed PMID: 15676037; PubMed Central PMCID: PMC1884746.

7: Kawakami Y, Nagino K, Shinkai K, Sobue S, Abe M, Ishiko J. [Nonclinical studies and clinical studies on fosfluconazole, a triazole antifungal agent (Prodif)]. Nihon Yakurigaku Zasshi. 2004 Jul;124(1):41-51. Review. Japanese. PubMed PMID: 15226621.

8: Sobue S, Tan K, Layton G, Eve M, Sanderson JB. Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers. Br J Clin Pharmacol. 2004 Jul;58(1):20-5. PubMed PMID: 15206988; PubMed Central PMCID: PMC1884549.

9: Sobue S, Tan K, Layton G, Leclerc V, Weil A. The effects of renal impairment on the pharmacokinetics and safety of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. Br J Clin Pharmacol. 2004 Jun;57(6):773-84. PubMed PMID: 15151523; PubMed Central PMCID: PMC1884522.

10: Sobue S, Tan K, Shaw L, Layton G, Hust R. Comparison of the pharmacokinetics of fosfluconazole and fluconazole after single intravenous administration of fosfluconazole in healthy Japanese and Caucasian volunteers. Eur J Clin Pharmacol. 2004 Jun;60(4):247-53. Epub 2004 Apr 22. PubMed PMID: 15103438.

11: Sobue S, Sekiguchi K, Shimatani K, Tan K. Pharmacokinetics and safety of Fosfluconazole after single intravenous bolus injection in healthy male Japanese volunteers. J Clin Pharmacol. 2004 Mar;44(3):284-92. PubMed PMID: 14973307.

Your view history

Fosfluconazole featured