CP-376395 HCl
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MedKoo CAT#: 524836

CAS#: 1013933-37-3 (HCl)

Description: CP 376395 hydrochloride is a potent and selective CRF-RI receptor antagonist (Ki value are 12 and >10000 nM for CRF-RI and CRF-RII receptors respectively).

Chemical Structure

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CP-376395 HCl
CAS# 1013933-37-3 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 524836
Name: CP-376395 HCl
CAS#: 1013933-37-3 (HCl)
Chemical Formula: C21H31ClN2O
Exact Mass: 0.00
Molecular Weight: 362.940
Elemental Analysis: C, 69.50; H, 8.61; Cl, 9.77; N, 7.72; O, 4.41

Price and Availability

Size Price Availability Quantity
5mg USD 275 2 Weeks
25mg USD 830 2 Weeks
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Related CAS #: 1013933-37-3 (HCl)   175140-00-8 (free base)    

Synonym: CP-376395 HCl; CP-376395; CP376395; UNII-5113G7FP34.

IUPAC/Chemical Name: 2-(mesityloxy)-3,6-dimethyl-N-(pentan-3-yl)pyridin-4-amine hydrochloride

InChi Key: UDIOZDHQQNYISB-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H

SMILES Code: CCC(CC)NC1=CC(=NC(=C1C)OC2=C(C=C(C=C2C)C)C)C.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 362.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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8: Bai Q, Shi D, Zhang Y, Liu H, Yao X. Exploration of the antagonist CP-376395 escape pathway for the corticotropin-releasing factor receptor 1 by random acceleration molecular dynamics simulations. Mol Biosyst. 2014 Jul;10(7):1958-67. doi: 10.1039/c4mb00037d. PubMed PMID: 24820411.

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13: Simms JA, Nielsen CK, Li R, Bartlett SE. Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395. Addict Biol. 2014 Jul;19(4):606-11. doi: 10.1111/adb.12024. Epub 2013 Jan 30. PubMed PMID: 23362976.

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