CI 922

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524715

CAS#: 97958-08-2

Description: CI 922 is an allergic mediator release inhibitor. It inhibits human neutrophil activation.

Chemical Structure

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CI 922
CAS# 97958-08-2
Instruction

Theoretical Analysis

MedKoo Cat#: 524715
Name: CI 922
CAS#: 97958-08-2
Chemical Formula: C26H30N10O6
Exact Mass: 0.00
Molecular Weight: 578.580
Elemental Analysis: C, 53.97; H, 5.23; N, 24.21; O, 16.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 97958-08-2   89224-56-6 (free base),  

Synonym: CI 922; CI-922; CI922; UNII-5VC7KY707F.

IUPAC/Chemical Name: 3,7-dimethoxy-4-phenyl-N-(1H-tetrazol-5-yl)-4H-furo[3,2-b]indole-2-carboxamide (S)-2-amino-5-guanidinopentanoate

InChi Key: OLFPNWJCEUTPNJ-VWMHFEHESA-N

InChi Code: InChI=1S/C20H16N6O4.C6H14N4O2/c1-28-12-8-9-14-13(10-12)16-15(26(14)11-6-4-3-5-7-11)17(29-2)18(30-16)19(27)21-20-22-24-25-23-20;7-4(5(11)12)2-1-3-10-6(8)9/h3-10H,1-2H3,(H2,21,22,23,24,25,27);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t;4-/m.0/s1

SMILES Code: n1(c2ccccc2)c2c(c(oc2c2cc(OC)ccc12)C(=O)Nc1nnn[nH]1)OC.C([C@@H](N)CCCNC(=N)N)(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 578.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Werns SW, Eller BT, Shea MJ, Simpson PJ, Dysko RC, Abrams GD, Lucchesi BR. Protection of reperfused ischemic canine myocardium by CI-922, a new inhibitor of leukocyte activation. J Cardiovasc Pharmacol. 1988;12(5):608-14. PubMed PMID: 2468062.

2: Wright CD, Hoffman MD, Thueson DO, Conroy MC. Inhibition of human neutrophil activation by the allergic mediator release inhibitor, CI-922: mechanism of inhibitory activity. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1110-7. PubMed PMID: 2825675.

3: Wright CD, Hoffman MD, Thueson DO, Conroy MC. Inhibition of human neutrophil activation by the allergic mediator release inhibitor, CI-922: differential inhibition of responses to a variety of stimuli. J Leukoc Biol. 1987 Jul;42(1):30-5. PubMed PMID: 2439626.

4: Adolphson RL, Finkel MP, Robichaud LJ. CI-922--a novel, potent antiallergic compound--II. Activity in animal models of allergy. Int J Immunopharmacol. 1987;9(1):51-60. PubMed PMID: 2438239.

5: Robichaud LJ, Stewart SF, Adolphson RL. CI-922--a novel, potent antiallergic compound--I. Inhibition of mediator release in vitro. Int J Immunopharmacol. 1987;9(1):41-9. PubMed PMID: 2438238.

6: Boctor AM, Pugsley TA. Effect of CI-922, a potential new antiallergy agent, on arachidonic acid metabolism in vitro. Inflammation. 1986 Dec;10(4):435-41. PubMed PMID: 2432012.

7: Eiseman IA, Reynolds DL, Johnson EL, Daftsios AC, Pachla LA. A validated liquid chromatographic method for the antiallergy agent CI-922 in dog and rat plasma. J Pharm Biomed Anal. 1986;4(4):491-6. PubMed PMID: 16867585.