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MedKoo CAT#: 318301

CAS#: 465-65-6 (free base)

Description: Naloxone is a μ-opioid receptor (MOR) inverse agonist. Naloxone has an extremely high affinity for μ-opioid receptors in the central nervous system (CNS). Its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at κ- (KOR) and δ-opioid receptors (DOR). The mechanism of action is not completely understood, but studies suggest it functions to produce withdrawal symptoms by competing for opiate receptor sites within the CNS (a competitive antagonist, not a direct agonist), thereby preventing the action of both endogenous and xenobiotic opiates on these receptors without directly producing any effects itself. Naloxone was approved for opioid overdose by the Food and Drug Administration in 1971.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1450 2 Weeks
1g USD 2250 2 Weeks
2g USD 3250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-22. Prices are subject to change without notice.

Naloxone free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318301
Name: Naloxone
CAS#: 465-65-6 (free base)
Chemical Formula: C19H21NO4
Exact Mass: 327.1471
Molecular Weight: 327.3743
Elemental Analysis: C, 69.71; H, 6.47; N, 4.28; O, 19.55

Related CAS #: 465-65-6 (free base)   357-08-4 (HCl)   51481-60-8 (HCl dihydrate)    

Synonym: Naloxone, Narcan, Evzio, Naloxona, Naloxonum

IUPAC/Chemical Name: (4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one


InChi Code: InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

SMILES Code: C=CCN1CC[C@]23[C@@H]4C(CC[C@@]2(O)[C@H]1CC5=C3C(O4)=C(O)C=C5)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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