WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317199
CAS#: 128470-16-6 (free base)
Description: Arbutamine is a cardiac stimulant. It stimulates adrenergic receptors. Arbutamine is a synthetic catecholamine with positive chronotropic and inotropic properties, used in echocardiography and diagnostic coronary angiography. Arbutamine binds to and activates beta-1 adrenergic receptors in the myocardium, thereby increasing heart rate and increasing force of myocardial contraction. Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately.
MedKoo Cat#: 317199
CAS#: 128470-16-6 (free base)
Chemical Formula: C18H23NO4
Exact Mass: 317.16271
Molecular Weight: 317.38
Elemental Analysis: C, 68.12; H, 7.30; N, 4.41; O, 20.16
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Related CAS #: 125251-66-3 (HCl) 128470-16-6 (free base) 130783-37-8 (free base)
Synonym: Genesa; Arbutaminum; Arbutamina;.
IUPAC/Chemical Name: 4-[(1R)-1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol
InChi Key: IIRWWTKISYTTBL-SFHVURJKSA-N
InChi Code: InChI=1S/C18H23NO4/c20-15-7-4-13(5-8-15)3-1-2-10-19-12-18(23)14-6-9-16(21)17(22)11-14/h4-9,11,18-23H,1-3,10,12H2/t18-/m0/s1
SMILES Code: C1=CC(=CC=C1CCCCNCC(C2=CC(=C(C=C2)O)O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 317.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
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8: Ruiz M, Takehana K, Petruzella FD, Watson DD, Beller GA, Glover DK. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70. Erratum in: J Nucl Med 2002 Oct;43(10):1376. PubMed PMID: 11994532.
9: Pierard LA, Melon PG, Lancellotti P, De Landsheere CM, Degueldre C, Kulbertus HE. Identification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography. Acta Cardiol. 2001 Dec;56(6):387-94. PubMed PMID: 11791807.
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