Spermidine trihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125936

CAS#: 334-50-9 (3HCl)

Description: Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.

Chemical Structure

img
Spermidine trihydrochloride
CAS# 334-50-9 (3HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 125936
Name: Spermidine trihydrochloride
CAS#: 334-50-9 (3HCl)
Chemical Formula: C7H22Cl3N3
Exact Mass: 253.09
Molecular Weight: 254.624
Elemental Analysis: C, 33.02; H, 8.71; Cl, 41.77; N, 16.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 334-50-9 (3HCl)   124-20-9 (free base)  

Synonym: Spermidine trihydrochloride; 334-50-9; Spermidine hydrochloride;

IUPAC/Chemical Name: N1-(3-aminopropyl)butane-1,4-diamine trihydrochloride

InChi Key: LCNBIHVSOPXFMR-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H

SMILES Code: Cl.Cl.Cl.NCCCCNCCCN

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 254.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and
disease. Science. 2018 Jan 26;359(6374):eaan2788. doi: 10.1126/science.aan2788.
PMID: 29371440.

2: Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F. Mechanisms
of spermidine-induced autophagy and geroprotection. Nat Aging. 2022
Dec;2(12):1112-1129. doi: 10.1038/s43587-022-00322-9. Epub 2022 Dec 22. PMID:
37118547.

3: Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL, Liu XQ, Liu HF, Cai WW, Huang SQ,
Wang Q, Zhang SJ. Spermidine and spermine delay brain aging by inducing
autophagy in SAMP8 mice. Aging (Albany NY). 2020 Apr 8;12(7):6401-6414. doi:
10.18632/aging.103035. Epub 2020 Apr 8. PMID: 32268299; PMCID: PMC7185103.

4: Liu X, Chen A, Liang Q, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen
Y, Ou JS, Yang P, Lu L, Yan J. Spermidine inhibits vascular calcification in
chronic kidney disease through modulation of SIRT1 signaling pathway. Aging
Cell. 2021 Jun;20(6):e13377. doi: 10.1111/acel.13377. Epub 2021 May 9. PMID:
33969611; PMCID: PMC8208796.

5: Fan J, Feng Z, Chen N. Spermidine as a target for cancer therapy. Pharmacol
Res. 2020 Sep;159:104943. doi: 10.1016/j.phrs.2020.104943. Epub 2020 May 24.
PMID: 32461185.

6: Zou D, Zhao Z, Li L, Min Y, Zhang D, Ji A, Jiang C, Wei X, Wu X. A
comprehensive review of spermidine: Safety, health effects, absorption and
metabolism, food materials evaluation, physical and chemical processing, and
bioprocessing. Compr Rev Food Sci Food Saf. 2022 May;21(3):2820-2842. doi:
10.1111/1541-4337.12963. Epub 2022 Apr 27. PMID: 35478379.

7: Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz
S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D,
Wirth M, Madeo F, Flöel A. Effects of Spermidine Supplementation on Cognition
and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized
Clinical Trial. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi:
10.1001/jamanetworkopen.2022.13875. PMID: 35616942; PMCID: PMC9136623.

8: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M. Spermidine, an autophagy
inducer, as a therapeutic strategy in neurological disorders. Neuropeptides.
2020 Oct;83:102083. doi: 10.1016/j.npep.2020.102083. Epub 2020 Aug 24. PMID:
32873420.

9: Shi YJ, Zhang J, Wang YW, Ding K, Yan Y, Xia CY, Li XX, He J, Zhang WK, Xu
JK. The untapped potential of spermidine alkaloids: Sources, structures,
bioactivities and syntheses. Eur J Med Chem. 2022 Oct 5;240:114600. doi:
10.1016/j.ejmech.2022.114600. Epub 2022 Jul 9. PMID: 35863273.

10: Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Spermidine: a
novel autophagy inducer and longevity elixir. Autophagy. 2010 Jan;6(1):160-2.
doi: 10.4161/auto.6.1.10600. PMID: 20110777.