WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 201891
CAS#: 227963-15-7 (free base)
Description: MK-0429 is a potent and selective inhibitor of the αvβ3 integrin, which showed therapeutic effects on bone turnover disease in men with hormone-refractory prostate cancer (HRPC) and bone metastases. MK-0429 was safe and efficacious in significantly decreasing melanoma metastasis in the lungs. MK-0429 may be useful for the prevention of metastatic melanoma.
MedKoo Cat#: 201891
Name: MK-0429
CAS#: 227963-15-7 (free base)
Chemical Formula: C23H29N5O4
Exact Mass: 439.22195
Molecular Weight: 439.51
Elemental Analysis: C, 62.85; H, 6.65; N, 15.93; O, 14.56
Related CAS #: 477841-10-4 (5 hydrate) 227963-15-7 (free base) 477841-08-0 (2 hydrate) 477841-09-1 (4 hydrate) 1125471-59-1 (0.5 hydrate)
Synonym: MK-0429; MK 0429; MK0429; L-000845704; L 000845704; L000845704.
IUPAC/Chemical Name: (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid
InChi Key: HGFOOLONGOBCMP-IBGZPJMESA-N
InChi Code: InChI=1S/C23H29N5O4/c1-32-20-9-7-17(15-25-20)19(14-21(29)30)28-13-12-27(23(28)31)11-3-5-18-8-6-16-4-2-10-24-22(16)26-18/h6-9,15,19H,2-5,10-14H2,1H3,(H,24,26)(H,29,30)/t19-/m0/s1
SMILES Code: O=C(O)C[C@@H](C1=CC=C(OC)N=C1)N2CCN(CCCC3=NC4=C(CCCN4)C=C3)C2=O
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 439.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Pickarski M, Gleason A, Bednar B, Duong le T. Orally active αvβ3 integrin
inhibitor MK-0429 reduces melanoma metastasis. Oncol Rep. 2015 Jun;33(6):2737-45.
doi: 10.3892/or.2015.3910. Epub 2015 Apr 9. PubMed PMID: 25872534; PubMed Central
PMCID: PMC4431436.
2: Rosenthal MA, Davidson P, Rolland F, Campone M, Xue L, Han TH, Mehta A, Berd
Y, He W, Lombardi A. Evaluation of the safety, pharmacokinetics and treatment
effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease
activity in men with hormone-refractory prostate cancer and bone metastases. Asia
Pac J Clin Oncol. 2010 Mar;6(1):42-8. doi: 10.1111/j.1743-7563.2009.01266.x.
PubMed PMID: 20398037.
