MK-0429

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 201891

CAS#: 227963-15-7

Description: MK-0429 is a potent and selective inhibitor of the αvβ3 integrin, which showed therapeutic effects on bone turnover disease in men with hormone-refractory prostate cancer (HRPC) and bone metastases. MK-0429 was safe and efficacious in significantly decreasing melanoma metastasis in the lungs. MK-0429 may be useful for the prevention of metastatic melanoma.


Price and Availability

Size
Price

1g
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Size
Price

2g
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Size
Price

5g
Ask price

MK-0429 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 201891
Name: MK-0429
CAS#: 227963-15-7
Chemical Formula: C23H29N5O4
Exact Mass: 439.22195
Molecular Weight: 439.51
Elemental Analysis: C, 62.85; H, 6.65; N, 15.93; O, 14.56


Synonym: MK-0429; MK 0429; MK0429; L-000845704; L 000845704; L000845704.

IUPAC/Chemical Name: (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid

InChi Key: HGFOOLONGOBCMP-IBGZPJMESA-N

InChi Code: InChI=1S/C23H29N5O4/c1-32-20-9-7-17(15-25-20)19(14-21(29)30)28-13-12-27(23(28)31)11-3-5-18-8-6-16-4-2-10-24-22(16)26-18/h6-9,15,19H,2-5,10-14H2,1H3,(H,24,26)(H,29,30)/t19-/m0/s1

SMILES Code: O=C(O)C[C@@H](C1=CC=C(OC)N=C1)N2CCN(CCCC3=NC4=C(CCCN4)C=C3)C2=O


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 
  
 
 


References

1: Pickarski M, Gleason A, Bednar B, Duong le T. Orally active αvβ3 integrin
inhibitor MK-0429 reduces melanoma metastasis. Oncol Rep. 2015 Jun;33(6):2737-45.
doi: 10.3892/or.2015.3910. Epub 2015 Apr 9. PubMed PMID: 25872534; PubMed Central
PMCID: PMC4431436.

2: Rosenthal MA, Davidson P, Rolland F, Campone M, Xue L, Han TH, Mehta A, Berd
Y, He W, Lombardi A. Evaluation of the safety, pharmacokinetics and treatment
effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease
activity in men with hormone-refractory prostate cancer and bone metastases. Asia
Pac J Clin Oncol. 2010 Mar;6(1):42-8. doi: 10.1111/j.1743-7563.2009.01266.x.
PubMed PMID: 20398037.