Phenylethylmalonamide hydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125271

CAS#: 80866-90-6 (hydrate)

Description: Phenylethylmalonamide (PEMA) is an important metabolite of primidone.

Chemical Structure

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Phenylethylmalonamide hydrate
CAS# 80866-90-6 (hydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 125271
Name: Phenylethylmalonamide hydrate
CAS#: 80866-90-6 (hydrate)
Chemical Formula: C11H16N2O3
Exact Mass: 224.12
Molecular Weight: 224.260
Elemental Analysis: C, 58.91; H, 7.19; N, 12.49; O, 21.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 80866-90-6 (hydrate)   7206-76-0 (free base)  

Synonym: 2-Ethyl-2-phenylmalonamide monohydrate; 80866-90-6; Phenylethylmalonamide hydrate; UNII-27L1MIN7YR; 27L1MIN7YR

IUPAC/Chemical Name: 2-ethyl-2-phenylpropanediamide;hydrate

InChi Key: FZSBWHZDTUPYRX-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H14N2O2.H2O/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8;/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15);1H2

SMILES Code: O=C(N)C(C1=CC=CC=C1)(CC)C(N)=O.[H]O[H]

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 224.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Baumel IP, Gallagher BB, Mattson RH. Phenylethylmalonamide (PEMA). An
important metabolite of primidone. Arch Neurol. 1972 Jul;27(1):34-41. doi:
10.1001/archneur.1972.00490130036005. PMID: 4626105.

2: Calzetti S, Findley LJ, Pisani F, Richens A. Phenylethylmalonamide in
essential tremor. A double-blind controlled study. J Neurol Neurosurg
Psychiatry. 1981 Oct;44(10):932-4. doi: 10.1136/jnnp.44.10.932. PMID: 7031184;
PMCID: PMC491180.

3: Yeary RA. Serum concentrations of primidone and its metabolites,
phenylethylmalonamide and phenobarbital, in the dog. Am J Vet Res. 1980
Oct;41(10):1643-5. PMID: 7224290.

4: Streete JM, Berry DJ, Pettit LI, Newbery JE. Phenylethylmalonamide serum
levels in patients treated with primidone and the effects of other antiepileptic
drugs. Ther Drug Monit. 1986;8(2):161-5. doi: 10.1097/00007691-198606000-00006.
PMID: 3088778.

5: Streete JM, Berry DJ, Jones JA, Groggin MJ. Clearance of
phenylethylmalonamide during haemodialysis of a patient with renal failure. Ther
Drug Monit. 1990 May;12(3):281-3. doi: 10.1097/00007691-199005000-00012. PMID:
2349613.

6: Pisani F, Richens A. Pharmacokinetics of phenylethylmalonamide (PEMA) after
oral and intravenous administration. Clin Pharmacokinet. 1983 May-
Jun;8(3):272-6. doi: 10.2165/00003088-198308030-00006. PMID: 6851372.