SUVN-502 dimesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125120

CAS#: 1791396-46-7 (dimesylate )

Description: Linrodostat, also known as BMS-986205, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. BMS-986205 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, BMS-986205 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).

Chemical Structure

img
SUVN-502 dimesylate
CAS# 1791396-46-7 (dimesylate )
Instruction

Theoretical Analysis

MedKoo Cat#: 125120
Name: SUVN-502 dimesylate
CAS#: 1791396-46-7 (dimesylate )
Chemical Formula: C23H32BrN3O9S3
Exact Mass: 669.05
Molecular Weight: 670.610
Elemental Analysis: C, 41.19; H, 4.81; Br, 11.92; N, 6.27; O, 21.47; S, 14.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1923833-60-6 (free base)   2221034-29-1 (mesylate)   1791396-46-7 (dimesylate )  

Synonym: SUVN-502 dimesylate; 1791396-46-7; Masupirdine (mesylate); Masupirdine mesylate; Masupirdine dimesylate; SUVN-502 mesylate; UNII-BFE1VOB95D; LINRODOSTAT DIMESYLATE

IUPAC/Chemical Name: 1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole dimethanesulfonate

InChi Key: LOZVXBFXRPRECW-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H24BrN3O3S.2CH4O3S/c1-23-9-11-24(12-10-23)14-16-15-25(20-8-7-17(28-2)13-18(16)20)29(26,27)21-6-4-3-5-19(21)22;2*1-5(2,3)4/h3-8,13,15H,9-12,14H2,1-2H3;2*1H3,(H,2,3,4)

SMILES Code: CS(O)(=O)=O.CS(O)(=O)=O.COC1=CC2=C(C=C1)N(C=C2CN3CCN(C)CC3)S(=O)(=O)C4=CC=CC=C4Br

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 670.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x