PSMA-I&T
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MedKoo CAT#: 556351

CAS#: 2192281-54-0

Description: PSMA-I&T is a PSMA-based radioligand. [177Lu]Lu-PSMA I&T can be used for potential treatment of metastatic castration-resistant prostate cancer. 67 Ga-PSMA I&T can be used for radioguided surgery of lymph node metastases with biochemical recurrence of prostate cancer.

Chemical Structure

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PSMA-I&T
CAS# 2192281-54-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 556351
Name: PSMA-I&T
CAS#: 2192281-54-0
Chemical Formula: C63H92IN11O23
Exact Mass: 1,497.54
Molecular Weight: 1,498.390
Elemental Analysis: C, 50.50; H, 6.19; I, 8.47; N, 10.28; O, 24.56

Price and Availability

Size Price Availability Quantity
1mg USD 950 Ready to ship
5mg USD 1950 Ready to ship
10mg USD 3650 Ready to ship
25mg USD 5950 Ready to ship
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Synonym: PSMA-I&T; PSMAI&T; PSMA I&T; PSMA-I-T; PSMA-IT;

IUPAC/Chemical Name: (3S,7S,26R,29R,32R)-29-benzyl-32-(4-hydroxy-3-iodobenzyl)-5,13,20,28,31,34-hexaoxo-37-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)-4,6,12,21,27,30,33-heptaazaheptatriacontane-1,3,7,26,37-pentacarboxylic acid

InChi Key: HPLNQICCRXHOIA-IEHTVPKNSA-N

InChi Code: InChI=1S/C63H92IN11O23/c64-42-34-41(18-21-49(42)76)36-46(67-52(79)22-20-48(62(96)97)75-32-30-73(38-55(84)85)28-26-72(37-54(82)83)27-29-74(31-33-75)39-56(86)87)57(88)69-47(35-40-12-4-3-5-13-40)58(89)68-43(59(90)91)14-8-10-24-65-50(77)16-6-1-2-7-17-51(78)66-25-11-9-15-44(60(92)93)70-63(98)71-45(61(94)95)19-23-53(80)81/h3-5,12-13,18,21,34,43-48,76H,1-2,6-11,14-17,19-20,22-33,35-39H2,(H,65,77)(H,66,78)(H,67,79)(H,68,89)(H,69,88)(H,80,81)(H,82,83)(H,84,85)(H,86,87)(H,90,91)(H,92,93)(H,94,95)(H,96,97)(H2,70,71,98)/t43-,44+,45+,46-,47-,48?/m1/s1

SMILES Code: IC(C=C1C[C@H](C(N[C@@H](C(N[C@@H](C(O)=O)CCCCNC(CCCCCCC(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC(CCC(N3CCN(CCN(CCN(CC3)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)=C(C=C1)O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: PSMA I&T is a potent PSMA (prostate-specific membrane antigen) inhibitor.
In vitro activity: To be determined
In vivo activity: PSMA I&T has potential as a theranostic tool for prostate cancer (PCa), with blocking agents like 2-PMPA mitigating kidney uptake concerns. PSMA I&T effectively localized in PSMA-expressing tumors but also accumulated in kidneys and salivary glands. However, coadministration of 2-PMPA reduced renal uptake, improving tumor visualization and reducing kidney toxicity during radionuclide therapy. Reference: Theranostics. 2016 Apr 12;6(6):849-61. https://pubmed.ncbi.nlm.nih.gov/27162555/

Preparing Stock Solutions

The following data is based on the product molecular weight 1,498.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Privé BM, Derks YHW, Rosar F, Franssen GM, Peters SMB, Khreish F, Bartholomä M, Maus S, Gotthardt M, Laverman P, Konijnenberg MW, Ezziddin S, Nagarajah J, Heskamp S. 89Zr-labeled PSMA ligands for pharmacokinetic PET imaging and dosimetry of PSMA-617 and PSMA-I&T: a preclinical evaluation and first in man. Eur J Nucl Med Mol Imaging. 2022 May;49(6):2064-2076. doi: 10.1007/s00259-021-05661-0. Epub 2021 Dec 21. PMID: 34932154. 2. Chatalic KL, Heskamp S, Konijnenberg M, Molkenboer-Kuenen JD, Franssen GM, Clahsen-van Groningen MC, Schottelius M, Wester HJ, van Weerden WM, Boerman OC, de Jong M. Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent. Theranostics. 2016 Apr 12;6(6):849-61. doi: 10.7150/thno.14744. PMID: 27162555; PMCID: PMC4860893.
In vitro protocol: To be determined
In vivo protocol: 1. Privé BM, Derks YHW, Rosar F, Franssen GM, Peters SMB, Khreish F, Bartholomä M, Maus S, Gotthardt M, Laverman P, Konijnenberg MW, Ezziddin S, Nagarajah J, Heskamp S. 89Zr-labeled PSMA ligands for pharmacokinetic PET imaging and dosimetry of PSMA-617 and PSMA-I&T: a preclinical evaluation and first in man. Eur J Nucl Med Mol Imaging. 2022 May;49(6):2064-2076. doi: 10.1007/s00259-021-05661-0. Epub 2021 Dec 21. PMID: 34932154. 2. Chatalic KL, Heskamp S, Konijnenberg M, Molkenboer-Kuenen JD, Franssen GM, Clahsen-van Groningen MC, Schottelius M, Wester HJ, van Weerden WM, Boerman OC, de Jong M. Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent. Theranostics. 2016 Apr 12;6(6):849-61. doi: 10.7150/thno.14744. PMID: 27162555; PMCID: PMC4860893.

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