Lenacapavir sodium

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MedKoo CAT#: 124472

CAS#: 2283356-12-5 (sodium)

Description: Lenacapavir, also known as GS-6207, is a HIV-1 capsid inhibitor. Lenacapavir shows anti-HIV activity. Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs). Lenacapavir demonstrated picomolar potency in vitro with no cross resistance to existing antiretroviral classes and potent antiviral activity in persons with HIV-1. In persons with HIV-1, there was no preexisting resistance to lenacapavir regardless of treatment history.

Chemical Structure

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Lenacapavir sodium
CAS# 2283356-12-5 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 124472
Name: Lenacapavir sodium
CAS#: 2283356-12-5 (sodium)
Chemical Formula: C39H31ClF10N7NaO5S2
Exact Mass: 989.13
Molecular Weight: 990.260
Elemental Analysis: C, 47.30; H, 3.16; Cl, 3.58; F, 19.19; N, 9.90; Na, 2.32; O, 8.08; S, 6.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 2283356-18-1 (HCl)   2189684-44-2 (free base)   2283356-12-5 (sodium)  

Synonym: Lenacapavir sodium; GS-HIV Sodium; GS-HIV Na; BDT58WJ9WE; Lenacapavir sodium [USAN]

IUPAC/Chemical Name: sodium;[4-chloro-7-[2-[(1S)-2-(3,5-difluorophenyl)-1-[[2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetyl]amino]ethyl]-6-(3-methyl-3-methylsulfonylbut-1-ynyl)pyridin-3-yl]-1-(2,2,2-trifluoroethyl)indazol-3-yl]-methylsulfonylazanide

InChi Key: SSXPGMNGIORJAQ-PZNXWHLTSA-M

InChi Code: InChI=1S/C39H32ClF10N7O5S2.Na/c1-36(2,63(3,59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43,44)45)54-35(30)55-64(4,61)62)31(51-21)27(13-18-11-19(41)14-20(42)12-18)52-28(58)16-56-34-29(33(53-56)39(48,49)50)24-15-25(24)38(34,46)47;/h5-8,11-12,14,24-25,27H,13,15-17H2,1-4H3,(H2,52,54,55,58);/q;+1/p-1/t24-,25+,27-;/m0./s1

SMILES Code: O=S([N-]C1=NN(CC(F)(F)F)C2=C1C(Cl)=CC=C2C3=CC=C(C#CC(S(=O)(C)=O)(C)C)N=C3[C@@H](NC(CN(N=C4C(F)(F)F)C5=C4[C@@]6([H])C[C@@]6([H])C5(F)F)=O)CC7=CC(F)=CC(F)=C7)(C)=O.[Na+]

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 990.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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