WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 204440
CAS#: 1228237-57-7 (disodium salt)
Description: ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of cancers.
MedKoo Cat#: 204440
Name: ARQ-736
CAS#: 1228237-57-7 (disodium salt)
Chemical Formula: C25H25N8Na2O8PS
Exact Mass:
Molecular Weight: 674.54
Elemental Analysis: C, 44.52; H, 3.74; N, 16.61; Na, 6.82; O, 18.97; P, 4.59; S, 4.75
ARQ-736, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: ARQ736; ARQ-736; ARQ 736.
IUPAC/Chemical Name: sodium (R)-(3-(5-(2-((1-((1-methyl-1H-pyrazol-3-yl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b]oxazol-6-yl)phenoxy)methyl phosphate
InChi Key: HXINDCTZKGGRDE-JPKZNVRTSA-L
InChi Code: InChI=1S/C25H27N8O8PS.2Na/c1-31-11-8-21(30-31)43(37,38)32-10-3-5-18(15-32)27-24-26-9-7-20(28-24)23-22(29-25-33(23)12-13-39-25)17-4-2-6-19(14-17)40-16-41-42(34,35)36;;/h2,4,6-9,11-14,18H,3,5,10,15-16H2,1H3,(H,26,27,28)(H2,34,35,36);;/q;2*+1/p-2/t18-;;/m1../s1
SMILES Code: O=P(O[Na])(O[Na])OCOC1=CC=CC(C(N=C2N3C=CO2)=C3C4=NC(N[C@@H](C5)CCCN5S(C6=NN(C=C6)C)(=O)=O)=NC=C4)=C1
The following data is based on the product molecular weight 674.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Related:
1228237-57-7 (ARQ-736 disodium salt)
1228237-47-5 (ARQ-736free acid)
ARQ 736 is an ATP-competitive pan-RAF kinase inhibitor discovered and developed at ArQule. This compound has been shown pre-clinically to be a potent inhibitor of mutant BRAF (V600E), wild-type BRAF and c-RAF.
Current developer: ArQule, Inc.