ARQ-736

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 204440

CAS#: 1228237-57-7 (disodium salt)

Description: ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of cancers.

Price and Availability

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Pricing updated 2020-10-22. Prices are subject to change without notice.

ARQ-736, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 204440
Name: ARQ-736
CAS#: 1228237-57-7 (disodium salt)
Chemical Formula: C25H25N8Na2O8PS
Exact Mass:
Molecular Weight: 674.54
Elemental Analysis: C, 44.52; H, 3.74; N, 16.61; Na, 6.82; O, 18.97; P, 4.59; S, 4.75

Synonym: ARQ736; ARQ-736; ARQ 736.

IUPAC/Chemical Name: sodium (R)-(3-(5-(2-((1-((1-methyl-1H-pyrazol-3-yl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b]oxazol-6-yl)phenoxy)methyl phosphate

InChi Key: HXINDCTZKGGRDE-JPKZNVRTSA-L

InChi Code: InChI=1S/C25H27N8O8PS.2Na/c1-31-11-8-21(30-31)43(37,38)32-10-3-5-18(15-32)27-24-26-9-7-20(28-24)23-22(29-25-33(23)12-13-39-25)17-4-2-6-19(14-17)40-16-41-42(34,35)36;;/h2,4,6-9,11-14,18H,3,5,10,15-16H2,1H3,(H,26,27,28)(H2,34,35,36);;/q;2*+1/p-2/t18-;;/m1../s1

SMILES Code: O=P(O[Na])(O[Na])OCOC1=CC=CC(C(N=C2N3C=CO2)=C3C4=NC(N[C@@H](C5)CCCN5S(C6=NN(C=C6)C)(=O)=O)=NC=C4)=C1

Technical Data

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO and soluble in water

Shelf Life:

>5 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO or water

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Additional Information

Related:
1228237-57-7 (ARQ-736 disodium salt)
1228237-47-5 (ARQ-736free acid)

ARQ 736 is an ATP-competitive pan-RAF kinase inhibitor discovered and developed at ArQule. This compound has been shown pre-clinically to be a potent inhibitor of mutant BRAF (V600E), wild-type BRAF and c-RAF.

Current developer: ArQule, Inc.

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