FRM-024

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465569

CAS#: 2085780-22-7

Description: FRM-024 is A Potent CNS-Penetrant Gamma Secretase Modulator. FRM-024 is a GSM preclinical candidate for familial Alzheimer’s disease.

Chemical Structure

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FRM-024
CAS# 2085780-22-7
Instruction

Theoretical Analysis

MedKoo Cat#: 465569
Name: FRM-024
CAS#: 2085780-22-7
Chemical Formula: C22H22ClN5O2
Exact Mass: 423.15
Molecular Weight: 423.901
Elemental Analysis: C, 62.34; H, 5.23; Cl, 8.36; N, 16.52; O, 7.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 2085780-22-7   2085780-85-2 (rotation -)   2085780-87-4 (rotation +),  

Synonym: FRM-024; FRM024; FRM 024;

IUPAC/Chemical Name: (5R,6S)-5-(4-chlorophenyl)-6-cyclopropyl-3-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

InChi Key: IOQORVDNYPOZPL-UXHICEINSA-N

InChi Code: InChI=1S/C22H22ClN5O2/c1-13-11-28(12-24-13)18-10-9-17(25-22(18)29-2)21-26-19(14-5-7-16(23)8-6-14)20(30-27-21)15-3-4-15/h5-12,15,19-20H,3-4H2,1-2H3,(H,26,27)/t19-,20+/m1/s1

SMILES Code: CC1=CN(C2=C(OC)N=C(C3=NO[C@@H](C4CC4)[C@@H](C5=CC=C(Cl)C=C5)N3)C=C2)C=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 423.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bursavich MG, Harrison BA, Acharya R, Costa DE, Freeman EA, Hrdlicka LA, Jin H, Kapadnis S, Moffit JS, Murphy D, Nolan SJ, Patzke H, Tang C, Van Voorhies HE, Wen M, Koenig G, Blain JF, Burnett DA. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Sep 22. doi: 10.1021/acs.jmedchem.1c00904. Epub ahead of print. PMID: 34550687.