Quinidine bisulfate

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MedKoo CAT#: 414248

CAS#: 747-45-5 (bisulfate)

Description: Quinidine bisulfate is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart.

Chemical Structure

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Quinidine bisulfate
CAS# 747-45-5 (bisulfate)
Instruction

Theoretical Analysis

MedKoo Cat#: 414248
Name: Quinidine bisulfate
CAS#: 747-45-5 (bisulfate)
Chemical Formula: C20H26N2O6S
Exact Mass: 0.00
Molecular Weight: 422.490
Elemental Analysis: C, 56.86; H, 6.20; N, 6.63; O, 22.72; S, 7.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 747-45-5 (bisulfate)   27555-34-6 (polygalacturonate)   56-54-2 (free base)   1668-99-1 (HCl)   7054-25-3 (gluconate)  

Synonym: Quinidine bisulfate; Biquin durules; Chinidin VUFB; Kinilentin; Optochinidin

IUPAC/Chemical Name: Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate (1:1)

InChi Key: AKYHKWQPZHDOBW-VJAUXQICSA-N

InChi Code: InChI=1S/C20H24N2O2.H2O4S/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t13-,14-,19+,20-;/m0./s1

SMILES Code: C=C[C@@H](C[N@@]1CC2)[C@@H]2C[C@@H]1[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.O=S(O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 422.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Belhassen B, Glick A, Viskin S. Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation. 2004 Sep 28;110(13):1731-7. doi: 10.1161/01.CIR.0000143159.30585.90. Epub 2004 Sep 20. PMID: 15381640.

2: Olsson G. To the editor--Market withdrawal of quinidine bisulfate (Kinidin Durules) in 2006. Heart Rhythm. 2010 Jun;7(6):864. doi: 10.1016/j.hrthm.2010.03.010. Epub 2010 Mar 10. PMID: 20226273.

3: Jamaludin A, Mohamed M, Navaratnam V, Mohamed N, Yeoh E, Wernsdorfer W. Single-dose comparative kinetics and bioavailability study of quinine hydrochloride, quinidine sulfate and quinidine bisulfate sustained-release in healthy male volunteers. Acta Leiden. 1988;57(1):39-46. PMID: 3245401.

4: Mahon WA, Mayersohn M, Inaba T. Disposition kinetics of two oral forms of quinidine. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):566-75. doi: 10.1002/cpt1976195part1566. PMID: 1277713.

5: Bottorff MB, Lalonde RL, Straughn AB. Comparison of high pressure liquid chromatography and fluorescence polarization immunoassay to assess quinidine pharmacokinetics. Biopharm Drug Dispos. 1987 May-Jun;8(3):213-21. doi: 10.1002/bdd.2510080303. PMID: 3297181.

6: Remon JP, Belpaire F, Van Severen R, Braeckman P. Interaction of antacids with antiarrhythmics. V. Effect of aluminium hydroxide and magnesium oxide on the bioavailability of quinidine, procainamide and propranolol in dogs. Arzneimittelforschung. 1983;33(1):117-20. PMID: 6681962.

7: Hii JT, Wyse DG, Gillis AM, Cohen JM, Mitchell LB. Propafenone-induced torsade de pointes: cross-reactivity with quinidine. Pacing Clin Electrophysiol. 1991 Nov;14(11 Pt 1):1568-70. doi: 10.1111/j.1540-8159.1991.tb02729.x. PMID: 1721143.

8: Huminer D, Dux S, Rosenfeld JB, Pitlik SD. Inadvertent sulfonylurea-induced hypoglycemia. A dangerous, but preventable condition. Arch Intern Med. 1989 Aug;149(8):1890-2. PMID: 2504124.

9: Rakhmanova MM, Sokolov SF. [Efficacy and safety of allapinine and quinidine bisulphate in the treatment of patients with persistent atrial fibrillation after cardioversion]. Kardiologiia. 2014;54(9):33-8. Russian. doi: 10.18565/cardio.2014.9.33-38. PMID: 25702400.

10: Knapp W, Lechleitner P. Relative Bioverfügbarkeit sowie Einfluss von Chindin in Form einer Retard-Zubereitung auf Blutdruck und EKG von gesunden Probanden [Relative bioavailability and influence of a quinidine retard-formulation on blood-pressure and ECG in healthy volunteers (author's transl)]. Arzneimittelforschung. 1981;31(9):1482-6. German. PMID: 7197960.