Tiapamil Free Base

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MedKoo CAT#: 413748

CAS#: 57010-31-8 (free base)

Description: Tiapamil Free Base is a phenylethylamine derivative that acts as a calcium antagonist showing hemodynamic effects in patients with acute myocardial infarction.

Chemical Structure

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Tiapamil Free Base
CAS# 57010-31-8 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 413748
Name: Tiapamil Free Base
CAS#: 57010-31-8 (free base)
Chemical Formula: C26H37NO8S2
Exact Mass: 555.20
Molecular Weight: 555.700
Elemental Analysis: C, 56.20; H, 6.71; N, 2.52; O, 23.03; S, 11.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 57010-32-9 (HCl)   57010-31-8 (free base)  

Synonym: Tiapamil Free Base

IUPAC/Chemical Name: 1,3-Dithiane-2-propanamine, 2-(3,4-dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methyl-, 1,1,3,3-tetraoxide

InChi Key: ZROUQTNYPCANTN-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H37NO8S2/c1-27(15-12-20-8-10-22(32-2)24(18-20)34-4)14-6-13-26(36(28,29)16-7-17-37(26,30)31)21-9-11-23(33-3)25(19-21)35-5/h8-11,18-19H,6-7,12-17H2,1-5H3

SMILES Code: CN(CCC1=CC=C(OC)C(OC)=C1)CCCC(S(CCC2)(=O)=O)(C3=CC=C(OC)C(OC)=C3)S2(=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 555.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Khurmi NS, Robinson CW, O'Hara MJ, Raftery EB. Tiapamil, a new calcium channel blocking agent for the treatment of effort induced chronic stable angina pectoris. Eur J Clin Pharmacol. 1986;30(4):387-92. doi: 10.1007/BF00607949. PMID: 3743614.

2: Hefti F, Gerold M, Holck M. Chronic administration of tiapamil prevents hemodynamic alterations accompanying development of high blood pressure in hypertensive rats. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1192-200. PMID: 6084779.

3: Opie LH, Muller CA, Thandroyen FT, Lloyd EA, Mabin T, Commerford PJ, Eichler HG. Tiapamil--a new calcium antagonist. S Afr Med J. 1985 Jun 1;67(22):881-3. PMID: 3890216.

4: Delmeire F. Tiapridal. Acta Psychiatr Belg. 1980 Mar-Apr;80(2):191-201. PMID: 7468281.

5: Gugger M, Crivelli AM, Galeazzi RL, Bachofen H. Effects of the calcium antagonist tiapamil on pulmonary gas exchange in patients with chronic obstructive pulmonary disease who receive salbutamol. Clin Pharmacol Ther. 1985 Jul;38(1):96-100. doi: 10.1038/clpt.1985.141. PMID: 4006380.

6: Storm TL, Badskjaer J, Hammer R, Kögler P. Tiapamil and hydrochlorothiazide: a double-blind comparison of two antihypertensive agents. J Clin Pharmacol. 1987 Jan;27(1):18-21. doi: 10.1177/009127008702700103. PMID: 3316301.

7: O'Keefe JC, Maltz MB, Butrous GS, Camm AJ. Efficacy of incremental doses of tiapamil on exercise performance in patients with chronic stable angina pectoris. Eur Heart J. 1986 Oct;7(10):843-7. doi: 10.1093/oxfordjournals.eurheartj.a061970. PMID: 3539614.

8: Dubner S, Gimeno G, Elencwajg B, Quinteiro R, Tronge J, Bertolasi C. Antiarrhythmic effect of tiapamil in patients with acute myocardial infarction. Cardiology. 1982;69 Suppl:172-80. doi: 10.1159/000173552. PMID: 7151078.

9: Saini RK, Fulmor IE, Antonaccio MJ. Effect of tiapamil and nifedepine during critical coronary stenosis and in the presence of adrenergic beta-receptor blockade in anesthetized dogs. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):770-6. doi: 10.1097/00005344-198209000-00012. PMID: 6182408.

10: Eigenmann R, Blaber L, Nakamura K, Thorens S, Haeusler G. Tiapamil, a new calcium antagonist. 1. Demonstration of calcium antagonistic activity and related studies. Arzneimittelforschung. 1981;31(9):1393-401. PMID: 7197945.