Dichlorisone (free base) | CAS# 7008-26-6 (free base) | synthetic glucocorticoid corticosteroid

Dichlorisone (free base)
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413695

CAS#: 7008-26-6 (free base)

Description: Dichlorisone (free base) is a synthetic glucocorticoid corticosteroid

Chemical Structure

Dichlorisone (free base)

CAS# 7008-26-6 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 413695
Name: Dichlorisone (free base)
CAS#: 7008-26-6 (free base)
Chemical Formula: C21H26Cl2O4
Exact Mass: 412.12
Molecular Weight: 413.340
Elemental Analysis: C, 61.02; H, 6.34; Cl, 17.15; O, 15.48

Price and Availability

Size	Price	Availability
5mg	USD 300	2 Weeks
25mg	USD 840	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 7008-26-6 (free base) 79-61-8 (acetate)

Synonym: Dichlorisone (free base); Diclorisona; Dichlorisonum

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: CZJXBZPJABCCRQ-BULBTXNYSA-N

InChi Code: InChI=1S/C21H26Cl2O4/c1-18-7-5-13(25)9-12(18)3-4-15-14-6-8-20(27,17(26)11-24)19(14,2)10-16(22)21(15,18)23/h5,7,9,14-16,24,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

SMILES Code: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1CC[C@@]2(C(CO)=O)O)CCC4=CC(C=C[C@]34C)=O)Cl)Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: ROBINSON HM Jr. Dichlorisone: a "topical" steroid. South Med J. 1960 Oct;53:1268-9. doi: 10.1097/00007611-196010000-00013. PMID: 13742295.

2: GRIBOFF SI. DICHLORISONE TREATMENT OF ALOPECIA. Med Times. 1963 Nov;91:1101-11. PMID: 14052165.

3: Gruol DJ, Bourgeois S. Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function. Cancer Res. 1997 Feb 15;57(4):720-7. PMID: 9044851.

4: Luo Y, Uboh CE, Soma LR, Guan FY, Rudy JA, Tsang DS. Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(10):1245-56. doi: 10.1002/rcm.1916. PMID: 15838928.

5: GANT JQ Jr. Dichlorisone in the management of poison ivy dermatitis. Med Ann Dist Columbia. 1961 May;30:267-8. PMID: 13703386.

6: JEANDIDIER P. L'AC'ETATE DE DICHLORISONE (VISODERM) EN TH'ERAPEUTIQUE DERMATOLOGIQUE LOCALE [DICHLORISONE ACETATE (VISODERM) IN LOCAL DERMATOLOGIC THERAPHY]. Ann Med Nancy. 1964 Aug-Sep;3:1062-5. French. PMID: 14229556.

7: SPIRANDELLI E, MIRANDE JL, GORI L. [Experience with a new steroid (dichlorisone) for topical ise in proctology]. Sem Med. 1963 Apr 18;122:663-6. Spanish. PMID: 13990175.

8: Griboff SI, Futterweit W. Effects of new 9,11-dihalogenated corticosteroids in various types of alopecia. II. Pituitary-adrenal responsiveness in patients treated with 16 alpha-methyl-dichlorisone alcohol. J Mt Sinai Hosp N Y. 1967 Mar-Apr;34(2):130-4. PMID: 5232041.

9: WEREIDE K. [Plastic covering for corticosteroid salves in psoriasis. Therapeutic trials with fluocinolone acetonide, triamcinolone acetonide and dichlorisone acetate]. Tidsskr Nor Laegeforen. 1963 Jun 15;83:1034-7. Norwegian. PMID: 13999986.

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Dichlorisone (free base) featured