Croconazole Free Base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413351

CAS#: 77175-51-0 (free base)

Description: Croconazole Free Base is an imidazole antifungal drug, a conazole antifungal drug, a member of monochlorobenzenes and an aromatic ether.

Chemical Structure

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Croconazole Free Base
CAS# 77175-51-0 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 413351
Name: Croconazole Free Base
CAS#: 77175-51-0 (free base)
Chemical Formula: C18H15ClN2O
Exact Mass: 310.09
Molecular Weight: 310.780
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 69.57; H, 4.87; Cl, 11.41; N, 9.01; O, 5.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 77174-66-4 (HCl)   77175-51-0 (free base)  

Synonym: Croconazole Free Base; Croconazolum

IUPAC/Chemical Name: 1-(1-(o-((m-Chlorobenzyl)oxy)phenyl)vinyl)imidazole

InChi Key: WHPAGCJNPTUGGD-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15ClN2O/c1-14(21-10-9-20-13-21)17-7-2-3-8-18(17)22-12-15-5-4-6-16(19)11-15/h2-11,13H,1,12H2

SMILES Code: C=C(N1C=CN=C1)C2=CC=CC=C2OCC3=CC=CC(Cl)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 310.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: El-Badry M, Fetih G, Shakeel F. Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations. Drug Deliv. 2014 Feb;21(1):34-43. doi: 10.3109/10717544.2013.843610. Epub 2013 Oct 14. PMID: 24116896.

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5: Akhtar MJ, Khan S, Roy IM, Jafri IA. High performance liquid chromatographic determination of phenoxetol, methyl paraben, ethyl paraben, n-propyl paraben, iso-butyl paraben, n-butyl paraben and croconazole.HCl. J Pharm Biomed Anal. 1996 Aug;14(11):1609-13. doi: 10.1016/0731-7085(96)01777-3. PMID: 8877869.

6: Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988 Apr;1(2):187-217. doi: 10.1128/cmr.1.2.187. PMID: 3069196; PMCID: PMC358042.

7: Scherr N, Röltgen K, Witschel M, Pluschke G. Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans. Antimicrob Agents Chemother. 2012 Dec;56(12):6410-3. doi: 10.1128/AAC.01383-12. Epub 2012 Sep 24. PMID: 23006761; PMCID: PMC3497166.

8: Steinmann A, Mayer G, Breit R, Agathos M. Allergic contact dermatitis from croconazole without cross-sensitivity to clotrimazole and bifonazole. Contact Dermatitis. 1996 Oct;35(4):255-6. doi: 10.1111/j.1600-0536.1996.tb02375.x. PMID: 8957655.

9: Meinicke K, Michel G. Croconazole: a new broad spectrum agent in the treatment of fungal skin infections. Int J Clin Pharmacol Res. 1994;14(4):139-48. PMID: 7607787.

10: Steinmann D, Barth J, Wozel G. Anti-inflammatory activity of croconazole, a broad-spectrum antimycotic agent, in the arachidonic acid-induced mouse ear swelling test. Skin Pharmacol. 1995;8(4):211-4. doi: 10.1159/000211349. PMID: 7488399.