Colterol HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413245

CAS#: 52872-37-4 (HCl)

Description: Colterol HCl is the salt form of Colterol (free base), a short-acting β2-adrenoreceptor agonist. Bitolterol, a prodrug for colterol, is used in the management of bronchospasm in asthma and chronic obstructive pulmonary disease.

Chemical Structure

img
Colterol HCl
CAS# 52872-37-4 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 413245
Name: Colterol HCl
CAS#: 52872-37-4 (HCl)
Chemical Formula: C12H20ClNO3
Exact Mass: 0.00
Molecular Weight: 261.750
Elemental Analysis: C, 55.07; H, 7.70; Cl, 13.54; N, 5.35; O, 18.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 17605-73-1 (mesylate)   18866-78-9 (free base)   52872-37-4 (HCl)   10255-14-8 (acetate)  

Synonym: Colterol HCl; 1,2-Benzenediol, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, hydrochloride

IUPAC/Chemical Name: 1,2-Benzenediol, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, hydrochloride

InChi Key: GWQNMEFTYFDDKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H19NO3.ClH/c1-12(2,3)13-7-11(16)8-4-5-9(14)10(15)6-8;/h4-6,11,13-16H,7H2,1-3H3;1H

SMILES Code: OC1=CC=C(C(O)CNC(C)(C)C)C=C1O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 261.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Walker SB, Kradjan WA, Bierman CW. Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37. doi: 10.1002/j.1875-9114.1985.tb03410.x. PMID: 3895171.

2: Friedel HA, Brogden RN. Bitolterol. A preliminary review of its pharmacological properties and therapeutic efficacy in reversible obstructive airways disease. Drugs. 1988 Jan;35(1):22-41. doi: 10.2165/00003495-198835010-00002. PMID: 3278878.

3: Kusayama T, Oka J, Yabana H, Adachi-Akahane S, Nagao T. Binding of a catechol derivative of denopamine (T-0509) and N-tert-butylnoradrenaline (Colterol) to beta 1- and beta 2-adrenoceptors. Biol Pharm Bull. 1994 Aug;17(8):1023-7. doi: 10.1248/bpb.17.1023. PMID: 7820101.

4: Kelly HW. New beta 2-adrenergic agonist aerosols. Clin Pharm. 1985 Jul- Aug;4(4):393-403. PMID: 2864159.

5: Aimoto T, Ito O, Kimura R, Murata T, Ito K. The influences of the route of administration on the metabolism and excretion of bitolterol, a new bronchodilator, in the rat. Xenobiotica. 1979 Mar;9(3):173-80. doi: 10.3109/00498257909038718. PMID: 473792.

6: Waldeck B, Jeppsson AB, Widmark E. Partial agonism and functional selectivity: a study on beta-adrenoceptor mediated effects in tracheal, cardiac and skeletal muscle. Acta Pharmacol Toxicol (Copenh). 1986 Mar;58(3):209-18. doi: 10.1111/j.1600-0773.1986.tb00096.x. PMID: 2872766.

7: Wilson TD, Fogarty DF. The effect of column age on system suitability parameters for an HPLC assay of bitolterol mesylate aerosols. J Chromatogr Sci. 1988 Feb;26(2):60-6. doi: 10.1093/chromsci/26.2.60. PMID: 3350902.

8: Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem. 2018;47(2):800-816. doi: 10.1159/000490033. Epub 2018 May 22. PMID: 29807365; PMCID: PMC6503657.

9: Park GB, Koss RF, Utter J, Edelson J. Determination of colterol in human plasma and urine by reversed-phase chromatography with amperometric detection. J Chromatogr. 1983 Apr 8;273(2):481-6. doi: 10.1016/s0378-4347(00)80975-5. PMID: 6345565.

10: Prados P, Higashidate S, Imai K, Sato Y, Nagao T. Sensitive determination of (-)-isoproterenol and (-)-(R)-1-(3,4- dihydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino] ethanol (T-0509), a cardiotonic agent, in rat plasma utilizing a fully automated catecholamine analyser. Biomed Chromatogr. 1994 Jan-Feb;8(1):49-51. doi: 10.1002/bmc.1130080113. PMID: 8130635.