Citalopram oxalate

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MedKoo CAT#: 412967

CAS#: 207559-01-1 (oxalate)

Description: Citalopram oxalate is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.

Chemical Structure

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Citalopram oxalate
CAS# 207559-01-1 (oxalate)
Instruction

Theoretical Analysis

MedKoo Cat#: 412967
Name: Citalopram oxalate
CAS#: 207559-01-1 (oxalate)
Chemical Formula: C22H23FN2O5
Exact Mass: 414.16
Molecular Weight: 414.430
Elemental Analysis: C, 63.76; H, 5.59; F, 4.58; N, 6.76; O, 19.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 207559-01-1 (oxalate)   59729-33-8 (free base)   59729-32-7 (HBr)  

Synonym: Citalopram oxalate; UNII-B5RDX2419X

IUPAC/Chemical Name: 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, ethanedioate (1:1)

InChi Key: KTGRHKOEFSJQNS-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)

SMILES Code: N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1.O=C(O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 414.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: de Diego HL, Bond AD, Dancer RJ. Formation of solid solutions between racemic and enantiomeric citalopram oxalate. Chirality. 2011 May;23(5):408-16. doi: 10.1002/chir.20943. Epub 2011 Apr 6. PMID: 21472783.

2: Burke WJ. Escitalopram. Expert Opin Investig Drugs. 2002 Oct;11(10):1477-86. doi: 10.1517/13543784.11.10.1477. PMID: 12387707.

3: Chen VC, Hsieh YH, Chen LJ, Hsu TC, Tzang BS. Escitalopram oxalate induces apoptosis in U-87MG cells and autophagy in GBM8401 cells. J Cell Mol Med. 2018 Feb;22(2):1167-1178. doi: 10.1111/jcmm.13372. Epub 2017 Nov 3. PMID: 29105282; PMCID: PMC5783874.

4: Xu JH, Jiang P. Efficacy of escitalopram oxalate for patients with post- stroke depression. Medicine (Baltimore). 2018 Apr;97(14):e0219. doi: 10.1097/MD.0000000000010219. PMID: 29620632; PMCID: PMC5902280.

5: Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH. An electronic health records study of long-term weight gain following antidepressant use. JAMA Psychiatry. 2014 Aug;71(8):889-96. doi: 10.1001/jamapsychiatry.2014.414. PMID: 24898363.

6: Valipour R, Yilmaz MB, Valipour E. Study of DNA-Binding Activity and Antibacterial Effect of Escitalopram Oxalate, an Extensively Prescribed Antidepressant. Drug Res (Stuttg). 2019 Oct;69(10):545-550. doi: 10.1055/a-0809-5044. Epub 2019 Jan 7. PMID: 30616249.

7: Badulla WFS, Atkoşar Z, Arli G, Şener E. Application of LC-ESI-MS/MS Method for Analysis of Escitalopram Oxalate in Human Urine and Pharmaceutical Dosage Forms. J Chromatogr Sci. 2020 Jan 23;58(2):91-97. doi: 10.1093/chromsci/bmz073. PMID: 31681957.

8: Khanna S, Chirinos RE, Venna S. Escitalopram oxalate (Lexapro)-induced acneiform eruption. J Am Acad Dermatol. 2012 Dec;67(6):e261-3. doi: 10.1016/j.jaad.2012.03.032. PMID: 23158626.

9: Ma L, Lu ZN, Hu P, Yao CJ. Neuroprotective effect of escitalopram oxalate in rats with chronic hypoperfusion. J Huazhong Univ Sci Technolog Med Sci. 2015 Aug;35(4):514-518. doi: 10.1007/s11596-015-1462-x. Epub 2015 Jul 31. PMID: 26223919.

10: Shen Y, Zhao Q, Yu Y, Tan Y, Zhang H, Xu X, Wang Z, Li Y, Hu J, Zhong J, Li H. Efficacy and safety of bupropion hydrochloride extended-release versus escitalopram oxalate in Chinese patients with major depressive disorder: Results from a randomized, double-blind, non-inferiority trial. J Affect Disord. 2019 Oct 1;257:143-149. doi: 10.1016/j.jad.2019.07.023. Epub 2019 Jul 5. PMID: 31301615.