Ciramadol hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412952

CAS#: 63323-46-6 (HCl)

Description: Ciramadol hydrochloride is the salt form of Ciramadol (free base), an opioid analgesic that was developed in the late 1970s and is related to phencyclidine, tramadol, tapentadol and venlafaxine. It is a mixed agonist-antagonist for the μ-opioid receptor with relatively low abuse potential and a ceiling on respiratory depression which makes it a relatively safe drug.

Chemical Structure

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Ciramadol hydrochloride
CAS# 63323-46-6 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 412952
Name: Ciramadol hydrochloride
CAS#: 63323-46-6 (HCl)
Chemical Formula: C15H24ClNO2
Exact Mass: 285.15
Molecular Weight: 285.810
Elemental Analysis: C, 63.04; H, 8.46; Cl, 12.40; N, 4.90; O, 11.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 51356-59-3 (free base)   63323-46-6 (HCl)  

Synonym: Ciramadol hydrochloride; WY15705 hydrochloride; WY-15705 hydrochloride; WY 15705 hydrochloride

IUPAC/Chemical Name: Phenol, 3-((dimethylamino)(2-hydroxycyclohexyl)methyl)-, hydrochloride, (1R-(1alpha(R*),2alpha))- (-)-

InChi Key: XBNIHQOJYIOGEU-YJCHVBGGSA-N

InChi Code: InChI=1S/C15H23NO2.ClH/c1-16(2)15(11-6-5-7-12(17)10-11)13-8-3-4-9-14(13)18;/h5-7,10,13-15,17-18H,3-4,8-9H2,1-2H3;1H/t13?,14-,15-;/m1./s1

SMILES Code: OC1=CC=CC([C@@H](N(C)C)C2[C@H](O)CCCC2)=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 285.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Reines HD, Hunt P, Rambo W, Loadholt CB. Oral ciramadol: a new analgesic for postoperative pain. J Clin Pharmacol. 1986 Feb;26(2):111-4. doi: 10.1002/j.1552-4604.1986.tb02917.x. PMID: 3753988.

2: Meacham RH Jr, Sisenwine SF, Liu AL, Kick CJ, Barinov I, Ruelius HW. Inhibition of ciramadol glucuronidation by benzodiazepines. Drug Metab Dispos. 1986 Jul-Aug;14(4):430-6. PMID: 2873990.

3: Stambaugh JE Jr, McAdams J. Comparison of the analgesic efficacy and safety oral ciramadol, codeine, and placebo in patients with chronic cancer pain. J Clin Pharmacol. 1987 Feb;27(2):162-6. doi: 10.1002/j.1552-4604.1987.tb02178.x. PMID: 3680568.

4: Preston KL, Bigelow GE, Liebson IA. Comparative evaluation of morphine, pentazocine and ciramadol in postaddicts. J Pharmacol Exp Ther. 1987 Mar;240(3):900-10. PMID: 3559982.

5: Hoyumpa AM, Brown MW, Johnson R, Troxell R, Snowdy P, Schenker S. Effects of liver disease on the disposition of ciramadol in humans. J Clin Pharmacol. 1989 Mar;29(3):217-24. doi: 10.1002/j.1552-4604.1989.tb03316.x. PMID: 2723108.

6: Rothbard RL, Schreiner BF, Yu PN. Hemodynamic and respiratory effects of dezocine, ciramadol, and morphine. Clin Pharmacol Ther. 1985 Jul;38(1):84-8. doi: 10.1038/clpt.1985.139. PMID: 3839174.

7: Haskins JT, Moyer JA, Muth EA, Sigg EB. DMI, Wy-45,030, Wy-45,881 and ciramadol inhibit locus coeruleus neuronal activity. Eur J Pharmacol. 1985 Sep 24;115(2-3):139-46. doi: 10.1016/0014-2999(85)90684-3. PMID: 2998818.

8: Lasagna L, Calimlim JF. Oral ciramadol in the treatment of postoperative pain. Clin Pharmacol Ther. 1985 Aug;38(2):176-82. doi: 10.1038/clpt.1985.155. PMID: 3839446.

9: Camu F, Heytens L, Claeys MA. Ciramadol as analgesic adjunct to anesthesia in short surgical procedures. Acta Anaesthesiol Belg. 1985 Dec;36(4):381-9. PMID: 3938175.

10: Downing JW, Brock-Utne JG, Holloway AM. Ciramadol--a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief. S Afr Med J. 1983 Dec 10;64(25):978-82. PMID: 6359486.