Cinpropazide maleate

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MedKoo CAT#: 412923

CAS#: 26328-00-7 (maleate)

Description: Cinpropazide maleate is a potent vasodilator exerting principal action on intramyocardial circulation increasing the blood flow of the coronary vessels & of the endocardic microcirculation.

Chemical Structure

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Cinpropazide maleate
CAS# 26328-00-7 (maleate)
Instruction

Theoretical Analysis

MedKoo Cat#: 412923
Name: Cinpropazide maleate
CAS#: 26328-00-7 (maleate)
Chemical Formula: C25H35N3O9
Exact Mass: 521.24
Molecular Weight: 521.570
Elemental Analysis: C, 57.57; H, 6.76; N, 8.06; O, 27.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 23887-47-0 (free base)   26328-00-7 (maleate)  

Synonym: Cinpropazide maleate; MD68111; MD-68111; MD 68111

IUPAC/Chemical Name: 1-Piperazineacetamide, N-(1-methylethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (Z)-2-butenedioate (1:1)

InChi Key: WOSAGTMAYYLCTD-GVTSEVKNSA-N

InChi Code: InChI=1S/C21H31N3O5.C4H4O4/c1-15(2)22-19(25)14-23-8-10-24(11-9-23)20(26)7-6-16-12-17(27-3)21(29-5)18(13-16)28-4;5-3(6)1-2-4(7)8/h6-7,12-13,15H,8-11,14H2,1-5H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-

SMILES Code: O=C(NC(C)C)CN1CCN(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CC1.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 521.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sakai K, Haga N, Fujisawa Y, Abiko Y. Effect of cinpropazide on ischemic myocardial acidosis in dogs. Arch Int Pharmacodyn Ther. 1985 Sep;277(1):83-91. PMID: 4062435.

2: Nonaka K, Ueno A. Effects of intravenously and orally administered cinpropazide on the coronary circulation in unanesthetized and unrestrained dogs. Arzneimittelforschung. 1985;35(10):1499-502. PMID: 4074404.

3: Oliver C, Rabiant J. Métabolisme du cinpropazide chez l'homme. Excrétion urinaire et taux plasmatique [The metabolism of cinpropazide in man. Urinary excretion and plasma concentration]. Ann Pharm Fr. 1975 Jun-Jul;33(6-7):301-12. French. PMID: 1220600.

4: Rabiant J, Oliver C, Ancher JF, Sergant M, Bouvet P. Métabolites urinaires du maléate de N-isopropyl ((triméthoxy-3,4,5 cinnamoyl)-4 pipérazinyl-1)-2 acétamide (cinpropazide) chez le Chien [Urinary metabolites of N-isopropyl 2-(4-(3,4,5-trimethoxycinnamoyl)-1-piperazinyl)acetamide (cinpropazide) in the dog]. Ann Pharm Fr. 1974 Mar-Apr;32(3-4):183-92. French. PMID: 4433119.