Cinepazet (free base)

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MedKoo CAT#: 412910

CAS#: 23887-41-4 (free base)

Description: Cinepazet (free base) is a vasodilator and is an ethyl ester derivative of cinepazic acid

Chemical Structure

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Cinepazet (free base)
CAS# 23887-41-4 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 412910
Name: Cinepazet (free base)
CAS#: 23887-41-4 (free base)
Chemical Formula: C20H28N2O6
Exact Mass: 392.19
Molecular Weight: 392.450
Elemental Analysis: C, 61.21; H, 7.19; N, 7.14; O, 24.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 50679-07-7 (maleate)   23887-41-4 (free base)  

Synonym: Cinepazet (free base); Cinepazetum; Cinepazeto

IUPAC/Chemical Name: 4-(1- Oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-1-piperazineacetic acid, ethyl ester

InChi Key: XDUOTWNXVDBCDY-VOTSOKGWSA-N

InChi Code: InChI=1S/C20H28N2O6/c1-5-28-19(24)14-21-8-10-22(11-9-21)18(23)7-6-15-12-16(25-2)20(27-4)17(13-15)26-3/h6-7,12-13H,5,8-11,14H2,1-4H3/b7-6+

SMILES Code: O=C(OCC)CN1CCN(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 392.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Levy JV. Cinepazet relaxation of aortic strips from normal and spontaneously hypertensive rats. Res Commun Chem Pathol Pharmacol. 1980 Jul;29(1):205-8. PMID: 7403676.

2: Cherchi A, Fonzo R. I calcioantagonisti nella terapia dell'angina pectoris da sforzo [Calcium antagonists in the therapy of angina pectoris of effort]. Boll Soc Ital Cardiol. 1978;(1 Suppl):114-30. Italian. PMID: 395961.

3: Sigel H, Janke J, Fleckenstein A. Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)). Recent Adv Stud Cardiac Struct Metab. 1975;6:121-6. PMID: 1197874.

4: Petralito A, Liuzzo A, Lunetta M, Mangiafico RA, Fiore CE. Calcio-antagonisti e metabolismo glicidico [Calcium antagonists and carbohydrate metabolism]. Boll Soc Ital Cardiol. 1978;23(9):1545-58. Italian. PMID: 553628.

5: Petralito A, Lunetta M, Liuzzo A, Fiore CE, Mangiafico RA. Influenza del maleato di cinepazato d'etile sulla curva da carico di glucosio in soggetti normali e in soggetti con metabolismo glicidico alterato [Influence of maleate of ethyl cinepazate on the curve of the glucose tolerance test in normal subjects and subjects with altered carbohydrate metabolism]. Boll Soc Ital Cardiol. 1979;24(2):177-81. Italian. PMID: 398219.

6: Novo S, Davì G, Riolo F, Pinto A, Avellone G, Fazio M. Valutazione, mediante test ergometrico, degli effetti della nifedipina, del verapamil e del maleato di cinepazato di etile nell'angina da sforzo [The ergometric test in the evaluation of the effects of nifedipine, verapamil and ethyl cinepazat maleate in angina of effort]. Boll Soc Ital Cardiol. 1980;25(2):139-48. Italian. PMID: 7236439.

7: Cherchi A, Fonzo R, Mercuro G, Lai C. Sull'influenza del maleato di cinepazato di etile sul test di tolleranza allo sforzo in pazienti affetti da angina pectoris [Influence of ethyl cinepazate maleate on the exercise tolerance test in patients with angina pectoris]. Boll Soc Ital Cardiol. 1978;23(1):265-80. Italian. PMID: 113021.