Isamoltane HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412646

CAS#: 99740-06-4 (HCl)

Description: Isamoltane is a serotonin 5-HT1 Receptor Antagonist

Chemical Structure

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Isamoltane HCl
CAS# 99740-06-4 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 412646
Name: Isamoltane HCl
CAS#: 99740-06-4 (HCl)
Chemical Formula: C16H23ClN2O2
Exact Mass: 310.14
Molecular Weight: 310.820
Elemental Analysis: C, 61.83; H, 7.46; Cl, 11.41; N, 9.01; O, 10.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 116861-00-8 (free base)   99740-06-4 (HCl)  

Synonym: Isamoltane; CGP361A; CGP-361A; CGP 361A

IUPAC/Chemical Name: 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(1H-pyrrol-1-yl)phenoxy)-, monohydrochloride

InChi Key: DCOXRJZVVPMXLY-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H22N2O2.ClH/c1-13(2)17-11-14(19)12-20-16-8-4-3-7-15(16)18-9-5-6-10-18;/h3-10,13-14,17,19H,11-12H2,1-2H3;1H

SMILES Code: OC(COC1=CC=CC=C1N2C=CC=C2)CNC(C)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 310.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun;337(6):609-20. doi: 10.1007/BF00175785. PMID: 2905765.

2: Bauer K, Dietersdorfer F, Kaik G. Assessment of beta-adrenergic receptor blockade after isamoltane, a 5-HT1-receptor active compound, in healthy volunteers. Clin Pharmacol Ther. 1993 Jun;53(6):675-83. doi: 10.1038/clpt.1993.89. PMID: 8099863.

3: Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343(1):1-6. doi: 10.1007/BF00180669. PMID: 1674359.

4: Hoyer D, Schoeffter P, Waeber C, Palacios JM. Serotonin 5-HT1D receptors. Ann N Y Acad Sci. 1990;600:168-81; discussion 181-2. doi: 10.1111/j.1749-6632.1990.tb16880.x. PMID: 2252308.

5: Middlemiss DN, Hutson PH. The 5-HT1B receptors. Ann N Y Acad Sci. 1990;600:132-47; discussion 347-48. doi: 10.1111/j.1749-6632.1990.tb16878.x. PMID: 2252306.

6: Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor. Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566.

7: Dawson LA, Nguyen HQ. The role of 5-HT(1A) and 5-HT(1B/1D) receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (+/-)pindolol. Neuropharmacology. 2000 Apr 3;39(6):1044-52. doi: 10.1016/s0028-3908(99)00192-6. PMID: 10727715.

8: Nogueira RL, Graeff FG. 5-HT mediation of the antiaversive effect of isamoltane injected into the dorsal periaqueductal grey. Behav Pharmacol. 1991 Feb;2(1):73-77. doi: 10.1097/00008877-199102000-00010. PMID: 11224050.

9: Chia JSM, Omar Farouk AA, Mohamad AS, Sulaiman MR, Perimal EK. Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors. Biomed Pharmacother. 2016 Oct;83:1303-1310. doi: 10.1016/j.biopha.2016.08.052. Epub 2016 Aug 27. PMID: 27570173.

10: Davidson C, Stamford JA. Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Brain Res Bull. 1997;43(4):405-9. doi: 10.1016/s0361-9230(97)00026-9. PMID: 9241443.