Azacosterol hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575163

CAS#: 1249-84-9 (HCl)

Description: Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone production, steroid hormones being synthesized from cholesterol.

Chemical Structure

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Azacosterol hydrochloride
CAS# 1249-84-9 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 575163
Name: Azacosterol hydrochloride
CAS#: 1249-84-9 (HCl)
Chemical Formula: C25H46Cl2N2O
Exact Mass: 460.30
Molecular Weight: 461.560
Elemental Analysis: C, 65.06; H, 10.05; Cl, 15.36; N, 6.07; O, 3.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 313-05-3 (free base)   1249-84-9 (HCl)    

Synonym: AI3-52592; Azacosterol dihydrochloride; Azacosterol 2HCl; Azacosterol hydrochloride; Azacosterol HCl; Azasterol; Diazacosterol hydrochloride

IUPAC/Chemical Name: 20,25-Diazachlolestenol dihydrochloride

InChi Key: BZFBDUQOBQHBSZ-DLCQERRASA-N

InChi Code: InChI=1S/C25H44N2O.2ClH/c1-24-13-11-19(28)17-18(24)7-8-20-21-9-10-23(25(21,2)14-12-22(20)24)27(5)16-6-15-26(3)4;;/h7,19-23,28H,6,8-17H2,1-5H3;2*1H/t19-,20-,21-,22-,23-,24-,25-;;/m0../s1

SMILES Code: Cl.Cl.CN(C)CCCN(C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 461.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Williams ML, Feingold KR, Grubauer G, Elias PM. Ichthyosis induced by cholesterol-lowering drugs. Implications for epidermal cholesterol homeostasis. Arch Dermatol. 1987 Nov;123(11):1535-8. PMID: 3674913.

2. Heacock AM, Klinger PD, Seguin EB, Agranoff BW. Cholesterol synthesis and nerve regeneration. J Neurochem. 1984 Apr;42(4):987-93. doi: 10.1111/j.1471-4159.1984.tb12701.x. PMID: 6699648.