Aminacrine hydrochloride monohydrate
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MedKoo CAT#: 573868

CAS#: 52417-22-8 (HCl hydrate)

Description: Aminacrine is a highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.

Chemical Structure

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Aminacrine hydrochloride monohydrate
CAS# 52417-22-8 (HCl hydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 573868
Name: Aminacrine hydrochloride monohydrate
CAS#: 52417-22-8 (HCl hydrate)
Chemical Formula: C13H13ClN2O
Exact Mass: 248.07
Molecular Weight: 248.710
Elemental Analysis: C, 62.78; H, 5.27; Cl, 14.25; N, 11.26; O, 6.43

Price and Availability

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5g USD 250 2 Weeks
25g USD 950 2 Weeks
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Related CAS #: 90-45-9 (free base)   134-50-9 (HCl)   52417-22-8 (HCl hydrate)    

Synonym: Aminacrine hydrochloride monohydrate, Aminacrine HCl monohydrate

IUPAC/Chemical Name: 9-Acridinamine, monohydrochloride, monohydrate

InChi Key: FTGPOQQGJVJDCT-UHFFFAOYSA-N

InChi Code: 1S/C13H10N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1-8H,(H2,14,15);1H

SMILES Code: c12c(c(c3ccccc3n1)[NH2+])cccc2.[ClH-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cerón-Carrasco JP, Ruiz J, Vicente C, de Haro C, Bautista D, Zúñiga J, Requena A. DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III), and Ir(III) Antitumoral Complexes and Their Interaction with DNA. J Chem Theory Comput. 2017 Aug 8;13(8):3898-3910. doi: 10.1021/acs.jctc.7b00139. Epub 2017 Jul 6. PubMed PMID: 28641006.

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4: Zhou D, Guo S, Zhang M, Liu Y, Chen T, Li Z. Mass spectrometry imaging of small molecules in biological tissues using graphene oxide as a matrix. Anal Chim Acta. 2017 Apr 15;962:52-59. doi: 10.1016/j.aca.2017.01.043. Epub 2017 Jan 31. PubMed PMID: 28231880.

5: Campbell AP, Wakelin LP, Denny WA, Finch AM. Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α1-Adrenergic Receptors. Mol Pharmacol. 2017 Feb;91(2):135-144. doi: 10.1124/mol.116.105874. Epub 2016 Nov 30. PubMed PMID: 27903755.

6: Kava HW, Murray V. CpG methylation increases the DNA binding of 9-aminoacridine carboxamide Pt analogues. Bioorg Med Chem. 2016 Oct 1;24(19):4701-4710. doi: 10.1016/j.bmc.2016.08.011. Epub 2016 Aug 8. PubMed PMID: 27567075.