Chromocarb | CAS#4940-39-0

Chromocarb
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 593047

CAS#: 4940-39-0 (free base)

Description: Chromocarb is used to eliminate lipoperoxidation postvitrectomy.

Chemical Structure

Chromocarb

CAS# 4940-39-0 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 593047
Name: Chromocarb
CAS#: 4940-39-0 (free base)
Chemical Formula: C10H6O4
Exact Mass: 190.03
Molecular Weight: 190.150
Elemental Analysis: C, 63.16; H, 3.18; O, 33.65

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 23915-80-2 (diethylamine) 4940-39-0 (free base)

Synonym: Chromocarb

IUPAC/Chemical Name: 4-Oxo-4H-1-benzopyran-2-carboxylic acid

InChi Key: RVMGXWBCQGAWBR-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H6O4/c11-7-5-9(10(12)13)14-8-4-2-1-3-6(7)8/h1-5H,(H,12,13)

SMILES Code: O=C(C1=CC(C2=CC=CC=C2O1)=O)O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 190.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dunbar EM, Buzzeo MP, Levine JB, Schold JD, Meier-Kriesche HU, Reddy V. The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease. Haematologica. 2008 Dec;93(12):1852-8. doi: 10.3324/haematol.13033. Epub 2008 Oct 22. PubMed PMID: 18945751.

2: Márquez R, Santángelo G, Sastre J, Goldschmidt P, Luyckx J, Pallardó FV, Viña J. Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin C against exercise-induced oxidative stress. Pharmacol Toxicol. 2001 Nov;89(5):255-8. PubMed PMID: 11881979.

3: Manzanas L, Jesús del Nozal M, Marcos MA, Cordero Y, Bernal JL, Goldschmidt P, Pastor JC. Oral flavonoids, chromocarb diethylamine salt and cyaninosides chloride, to eliminate lipoperoxidation postvitrectomy. Exp Eye Res. 2002 Jan;74(1):23-8. PubMed PMID: 11878815.

4: Bourret F, Lapalus P, Maurizis JC, Nicolas C. [Kinetic study of 14C chromocarb in the pigmented rabbit after a single instillation]. Ophtalmologie. 1988 Jul-Sep;2(3):257-9. French. PubMed PMID: 3247183.

5: Thebault JJ, Thiercelin JF, Faurie M. [Double-blind controlled study of the effects of diethylamine chromocarb on venous compliance and capillary resistance in man. Pharmacological effect/plasma concentrations ratio]. Therapie. 1988 Jan-Feb;43(1):39-43. French. PubMed PMID: 3358250.

6: Godeau G, Gavignet C, Groult N, Robert AM. Effect of chromocarb diethylamine on the permeability of the blood-brain barrier. Clin Physiol Biochem. 1987;5(1):15-26. PubMed PMID: 3034470.

7: Aiache JM, Faurie M, Sibaud Y, Kaftelip JP, Aiache S. The effect of food and time of administration on the absorption of diethylamine chromocarbe. Biopharm Drug Dispos. 1986 May-Jun;7(3):301-7. PubMed PMID: 3730530.

8: Lapalus P, Bayer V, Lapalus F. [Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits]. J Fr Ophtalmol. 1986;9(2):123-6. French. PubMed PMID: 3745792.

9: Spano VS. [Clinical study of chromocarb diethylamine in the treatment of peripheral venous insufficiency]. Ann Cardiol Angeiol (Paris). 1984 Nov;33(7):485-7. French. PubMed PMID: 6391359.

10: Spano V, Mancini A, Slatopolsky-Cantis M. [Evaluation of the venotropic effect of chromocarb diethylamine in patients with varices, using 133Xe]. Ann Cardiol Angeiol (Paris). 1984 Oct;33(6):407-10. French. PubMed PMID: 6497304.

11: Soyeux A, Debrousse JY, Le Devehat C, Lemoine A, Roux E, Cirette B. [Effect of chromocarbe diethylamine in the treatment of diabetic retinopathy]. Bull Soc Ophtalmol Fr. 1981 Oct;81(10):783-5. French. PubMed PMID: 7332980.

12: Copé R. [Value of fludarene in certain forms of hemorrhagic anal inflammations]. Med Chir Dig. 1981;10(3):281-2. French. PubMed PMID: 7266138.

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