Diatrizoate meglumine | CAS#131-49-7 | X-ray contrast medium

Diatrizoate meglumine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461218

CAS#: 131-49-7 (meglumine)

Description: Diatrizoate meglumine is the meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography.

Chemical Structure

Diatrizoate meglumine

CAS# 131-49-7 (meglumine)

Instruction

Theoretical Analysis

MedKoo Cat#: 461218
Name: Diatrizoate meglumine
CAS#: 131-49-7 (meglumine)
Chemical Formula: C18H26I3N3O9
Exact Mass: 808.88
Molecular Weight: 809.130
Elemental Analysis: C, 26.72; H, 3.24; I, 47.05; N, 5.19; O, 17.80

Price and Availability

Size	Price	Availability
10g	USD 450	2 weeks
25g	USD 850	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Diatrizoate meglumine; Hypaque; Reno; Renocal; Renografin; Renovist; Sinografin; Unipaque;

IUPAC/Chemical Name: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 3,5-diacetamido-2,4,6-triiodobenzoate

InChi Key: MIKKOBKEXMRYFQ-WZTVWXICSA-N

InChi Code: InChI=1S/C11H9I3N2O4.C7H17NO5/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,17)(H,16,18)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

SMILES Code: O=C(O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 809.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Peterson CM, Lin M, Pilgram T, Heiken JP. Prospective randomized trial of iohexol 350 versus meglumine sodium diatrizoate as an oral contrast agent for abdominopelvic computed tomography. J Comput Assist Tomogr. 2011 Mar-Apr;35(2):202-5. doi: 10.1097/RCT.0b013e3182058e76. PubMed PMID: 21412090.

2: Hayman LA, Pagani JJ, Serur JR, Hinck VC. Impermeability of the blood-brain barrier to intravenous high-iodine-dose meglumine diatrizoate in the normal dog. AJNR Am J Neuroradiol. 1984 Jul-Aug;5(4):409-11. PubMed PMID: 6205572.

3: Shea JJ, Emmett JR, Harell M. Evaluation of diatrizoate meglumine (Hypaque) in treatment of sudden hearing loss. Laryngoscope. 1977 Nov;87(11):1809-14. PubMed PMID: 916773.

4: Jacobson ED, Eldon C, Fondacaro JD. Effects of a rapid injection into the canine superior mesenteric artery of diatrizoate meglumine and diatrizoate sodium (Renografin-76). Cardiovasc Intervent Radiol. 1980;3(3):159-62. PubMed PMID: 7407811.

5: Sam MC, Gutmann L. Spinal myoclonus following intrathecal administration of diatrizoate meglumine. J Neuroimaging. 1996 Oct;6(4):256-8. PubMed PMID: 8903083.

6: Agwu KK, Mgbor S, Ogbu SO, Okeji M. The effect of in-vivo intravenous administration of sodium meglumine diatrizoate on some haematological parameters. Niger J Med. 2007 Oct-Dec;16(4):360-3. PubMed PMID: 18080596.

7: Bernardino ME, Fishman EK, Jeffrey RB Jr, Brown PC. Comparison of iohexol 300 and diatrizoate meglumine 60 for body CT: image quality, adverse reactions, and aborted/repeated examinations. AJR Am J Roentgenol. 1992 Mar;158(3):665-7. PubMed PMID: 1739017.

8: Kido DK, Morris TW, Ekholm S, Plassche W, Erickson JL. Comparison of iohexol and meglumine-Na diatrizoate in cerebral angiography. Acta Radiol Suppl. 1983;366:142-6. PubMed PMID: 6591738.

9: Miller SH. Anaphylactoid reaction after oral administration of diatrizoate meglumine and diatrizoate sodium solution. AJR Am J Roentgenol. 1997 Apr;168(4):959-61. PubMed PMID: 9124149.

10: Belle MB, Leffa DD, Mazzorana D, De Andrade VM. Evaluation of the mutagenic effect of the iodinated contrast medium Urografina® 292 using the micronucleus test in mouse bone marrow cells. An Acad Bras Cienc. 2013 Apr-Jun;85(2):737-44. doi: 10.1590/S0001-37652013000200018. PubMed PMID: 23828339.

11: Dean PB. Extravascular distribution of intravascular meglumine diatrizoate: effect of concentration and dose. Ann Radiol (Paris). 1978 May-Jun;21(4-5):303-5. PubMed PMID: 718086.

12: Owman T. Comparison of the excretion of sodium and meglumine diatrizoate at urography with simulated compression: an experimental study in the rat. Acta Pharmacol Toxicol (Copenh). 1981 Jul;49(1):21-7. PubMed PMID: 7336961.

13: Schmidt BJ, Foley WD, Bohorfoush AG. Toxic epidermal necrolysis related to oral administration of diluted diatrizoate meglumine and diatrizoate sodium. AJR Am J Roentgenol. 1998 Nov;171(5):1215-6. PubMed PMID: 9798850.

14: Sackett JF, Bergsjordet B, Seeger JF, Kieffer SA. Digital subtraction angiography. Comparison of meglumine-Na diatrizoate with iohexol. Acta Radiol Suppl. 1983;366:81-4. PubMed PMID: 6382939.

15: Yaghmai V, Harapanhalli RS, Patel YD, Baker SR, Rao DV. Effects of diatrizoate and iopamidol on spermatogenesis. Invest Radiol. 1993 Dec;28(12):1160-4. PubMed PMID: 8307722.

16: Turpeinen U, Pomoell UM. Liquid chromatographic determination of meglumine diatrizoate in human plasma and urine. J Chromatogr. 1986 Apr 25;377:460-5. PubMed PMID: 3486875.

17: Schmidek HH, Moreira D, Harder DR. Diatrizoate meglumine-induced dilation of rat basilar artery: an in vitro study. Neurosurgery. 1983 Feb;12(2):137-41. PubMed PMID: 6835495.

18: Hilz MJ, Huk W, Schellmann B, Sörgel F, Druschky KF. Fatal complications after myelography with meglumine diatrizoate. Neuroradiology. 1990;32(1):70-3. PubMed PMID: 2333138.

19: Dean PB, Kormano M. Intra-arterial bolus of 125I labeled meglumine diatrizoate. Early extravascular distribution. Acta Radiol Diagn (Stockh). 1977 Jul;18(4):425-32. PubMed PMID: 920233.

20: Norby LH, DiBona GF. The renal vascular effects of meglumine diatrizoate. J Pharmacol Exp Ther. 1975 Jun;193(3):932-40. PubMed PMID: 1151740.

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