Chloracyzine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558505

CAS#: 800-22-6 (free base)

Description: Chloracyzine is a drug produced a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. Chloracyzine produced an insignificant increase in arterial pressure; heart rate increased slightly in the open-chest experiments but not in the isolated heart. It is suggested that reduced oxygen uptake after chloracyzine is realized through improved efficiency in the use of oxygen.

Chemical Structure

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Chloracyzine
CAS# 800-22-6 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 558505
Name: Chloracyzine
CAS#: 800-22-6 (free base)
Chemical Formula: C8H4Cl6
Exact Mass: 309.84
Molecular Weight: 312.820
Elemental Analysis: C, 30.72; H, 1.29; Cl, 67.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 1045-82-5 (HCl)   800-22-6 (free base)  

Synonym: Chloracyzine; Chlorazicine; Chloroacizin; Chloroacizine; Chloroacyzin;

IUPAC/Chemical Name: 10H-Phenothiazine, 2-chloro-10-(3-(diethylamino)-1-oxopropyl)- (9CI)

InChi Key: OTEKOJQFKOIXMU-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H4Cl6/c9-7(10,11)5-1-2-6(4-3-5)8(12,13)14/h1-4H

SMILES Code: ClC(C1=CC=C(C(Cl)(Cl)Cl)C=C1)(Cl)Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 312.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kisin IE. On the decrease of myocardial oxygen consumption induced by chloracyzine. Br J Pharmacol. 1976 Oct;58(2):189-92. PubMed PMID: 974382; PubMed Central PMCID: PMC1667375.

2: Saratikov AS, Dmitrienko VF. Effects of papaverine, chloracyzine, and bencyclane on local blood flow and oxygen tension in cat brain. Cor Vasa. 1975;17(2):125-32. PubMed PMID: 1157501.

3: Saratikov AS, Usov LA, Voloshina E, Sakharova SA. The effect of chloracyzine upon cerebral circulation and some indices of cerebral metabolism. Cor Vasa. 1969;11(4):279-86. PubMed PMID: 5373324.

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7: Chukhlova EA, Sadykov IuKh, Kholmukhamedov EL, Grenader AK. [Effect of trimecaine, ajmaline, stenopril and chloracizine on fluctuations in K+ currents in rat liver mitochondria]. Ukr Biokhim Zh (1978). 1984 Mar-Apr;56(2):207-10. Russian. PubMed PMID: 6719571.

8: VIKHLIAEV IuI, KAVERINA NV. [Pharmacology of chloracizine]. Farmakol Toksikol. 1959 Jan-Feb;22(1):28-33. Russian. PubMed PMID: 13653121.

9: ERINA EV. [Chloracizine therapy of patients with coronary insufficiency]. Klin Med (Mosk). 1961 Jun;39:95-100. Russian. PubMed PMID: 13697164.

10: Thomson FJ, Mitchell R. Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue. Mol Cell Endocrinol. 1993 Sep;95(1-2):75-83. PubMed PMID: 8243810.

11: Robinson JJ, Watson F, Bucknall RC, Edwards SW. Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors/signal transduction systems. FEMS Immunol Med Microbiol. 1994 Mar;8(3):249-57. PubMed PMID: 8004062.

12: Buryĭ VA, Gurkovskaia AV, Gokina NI, Shuba MF. [Mechanism of action of chloracizine and stenopril on the electric and contractile activity of the smooth muscle of the portal vein of the rabbit]. Fiziol Zh. 1986 Jul-Aug;32(4):413-9. Russian. PubMed PMID: 3743816.

13: Thomson FJ, Johnson MS, Mitchell R, Wolbers B. Evidence for a role of phospholipase A2 in the mechanism of LHRH priming in rat anterior pituitary tissue. J Endocrinol. 1994 Apr;141(1):15-31. PubMed PMID: 8014598.

14: Bolotina V, Courtney KR, Khodorov B. Gate-dependent blockade of sodium channels by phenothiazine derivatives: structure-activity relationships. Mol Pharmacol. 1992 Sep;42(3):423-31. PubMed PMID: 1328843.

15: Roldan ER, Mollinedo F. Diacylglycerol stimulates the Ca2(+)-dependent phospholipase A2 of ram spermatozoa. Biochem Biophys Res Commun. 1991 Apr 15;176(1):294-300. PubMed PMID: 2018523.

16: Sichko AI, Godiatskiĭ VE. [Extraction of chloracizine thiocyanate complex of cobalt]. Farmatsiia. 1970 Nov-Dec;19(6):49-54. Russian. PubMed PMID: 5510379.

17: Korolenko CP, Volkov PP, Pantelejev VI. [Clinical and experimental observations with chloracizine]. Cesk Psychiatr. 1968 Oct;64(5):345-8. Czech. PubMed PMID: 5701273.

18: Vorontsov VV. [The mechanism of the diuretic action of chlorazicin]. Biull Eksp Biol Med. 1975 Nov;80(11):53-7. Russian. PubMed PMID: 1218263.

19: Tarasiewicz M, Puzanowska-Tarasiewicz H. Determination of phenothiazine derivatives. IV. Colorimetric determination of chloracizine by means of iodobismuthite. Acta Pol Pharm. 1972;29(1):26-35. PubMed PMID: 5055284.

20: Avakumov V, Müller D, Glöckner R, Klinger W. The influence of chloracizine (Ch) and ftoracizine (Ft) on hexobarbital sleeping time, ethylmorphine N-demethylation and cytochrome P450 and b5 concentration in rat liver. Biochem Pharmacol. 1978;27(17):2177-9. PubMed PMID: 728169.