Articaine HCl | CAS# 23964-57-0 (HCl) | local anesthetic

Articaine HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561391

CAS#: 23964-57-0 (HCl)

Description: Articaine HCl is a local anesthetic. Articaine HCl blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve. Used for dental purposes.

Chemical Structure

Articaine HCl

CAS# 23964-57-0 (HCl)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561391
Name: Articaine HCl
CAS#: 23964-57-0 (HCl)
Chemical Formula: C13H21ClN2O3S
Exact Mass: 0.00
Molecular Weight: 320.830
Elemental Analysis: C, 48.67; H, 6.60; Cl, 11.05; N, 8.73; O, 14.96; S, 9.99

Price and Availability

Size	Price	Availability
100mg	USD 350	2 Weeks
500mg	USD 890	2 Weeks
1g	USD 1400	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 23964-58-1 (free base) 23964-57-0 (HCl)

Synonym: Articaine HCl; Articaine Hydrochloride; Carticaine HCl; Hoe-40045; Hoe-045; Carticaine Hydrochloride;

IUPAC/Chemical Name: Methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate Hydrochloride

InChi Key: GDWDBGSWGNEMGJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H

SMILES Code: O=C(C1=C(NC(C(NCCC)C)=O)C(C)=CS1)OC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Articaine hydrochloride (Hoe-045) is used in dental.
In vitro activity:	TBD
In vivo activity:	The evaluation of critical biomarkers has a significant impact on the prognosis of the disease. Therefore, the effect of ART (Articaine) was initially assessed on BUN, CRE, and sCysC, which were known to be characteristic markers for the kidney, and the results are presented in Figure 1. The levels of BUN, CRE, and sCysC were found elevated in the LPS-treated rat group as compared to control, whereas, in the ART-treated group, the level of these biomarkers were found to be significantly decreased in a dose-dependent manner. Reference: J Biochem Mol Toxicol. 2020 Oct;34(10):e22554. https://pubmed.ncbi.nlm.nih.gov/32687258/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.5	123.12
	DMF	20.0	62.34
	Ethanol	34.5	107.53
	PBS (pH 7.2)	10.0	31.17
	Water	64.0	199.48

Preparing Stock Solutions

The following data is based on the product molecular weight 320.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Rodrigues da Silva GH, Geronimo G, García-López JP, Ribeiro LNM, de Moura LD, Breitkreitz MC, Feijóo CG, de Paula E. Articaine in functional NLC show improved anesthesia and anti-inflammatory activity in zebrafish. Sci Rep. 2020 Nov 12;10(1):19733. doi: 10.1038/s41598-020-76751-6. PMID: 33184457; PMCID: PMC7665027. 2. Zhao G, Lu S, Li L, Fan X. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554. doi: 10.1002/jbt.22554. Epub 2020 Jul 20. PMID: 32687258.
In vitro protocol:	TBD
In vivo protocol:	1. Rodrigues da Silva GH, Geronimo G, García-López JP, Ribeiro LNM, de Moura LD, Breitkreitz MC, Feijóo CG, de Paula E. Articaine in functional NLC show improved anesthesia and anti-inflammatory activity in zebrafish. Sci Rep. 2020 Nov 12;10(1):19733. doi: 10.1038/s41598-020-76751-6. PMID: 33184457; PMCID: PMC7665027. 2. Zhao G, Lu S, Li L, Fan X. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554. doi: 10.1002/jbt.22554. Epub 2020 Jul 20. PMID: 32687258.

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1: Shirvani A, Shamszadeh S, Eghbal MJ, Marvasti LA, Asgary S. Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. Clin Oral Investig. 2017 Jan;21(1):43-52. doi: 10.1007/s00784-016-1974-1. Epub 2016 Nov 11. Review. PubMed PMID: 27837343.

2: Yeung V. Articaine--to use or not to use? SAAD Dig. 2016 Jan;32:50-4. Review. PubMed PMID: 27145561.

3: Su N, Li C, Wang H, Shen J, Liu W, Kou L. Efficacy and safety of articaine versus lidocaine for irreversible pulpitis treatment: A systematic review and meta-analysis of randomised controlled trials. Aust Endod J. 2016 Apr;42(1):4-15. doi: 10.1111/aej.12125. Review. PubMed PMID: 27062318.

4: Gazal G, Fareed WM, Zafar MS. Role of intraseptal anesthesia for pain-free dental treatment. Saudi J Anaesth. 2016 Jan-Mar;10(1):81-6. doi: 10.4103/1658-354X.169482. Review. PubMed PMID: 26955316; PubMed Central PMCID: PMC4760049.

5: Bartlett G, Mansoor J. Articaine buccal infiltration vs lidocaine inferior dental block - a review of the literature. Br Dent J. 2016 Feb 12;220(3):117-20. doi: 10.1038/sj.bdj.2016.93. Review. PubMed PMID: 26868800.

6: Kung J, McDonagh M, Sedgley CM. Does Articaine Provide an Advantage over Lidocaine in Patients with Symptomatic Irreversible Pulpitis? A Systematic Review and Meta-analysis. J Endod. 2015 Nov;41(11):1784-94. doi: 10.1016/j.joen.2015.07.001. Epub 2015 Aug 17. Review. PubMed PMID: 26293174.

7: Kakroudi SH, Mehta S, Millar BJ. Articaine hydrochloride: is it the solution? Dent Update. 2015 Jan-Feb;42(1):88-90, 92-3. Review. PubMed PMID: 26062283.

8: Brockmann WG. Mepivacaine: a closer look at its properties and current utility. Gen Dent. 2014 Nov-Dec;62(6):70-5; quiz 76. Review. PubMed PMID: 25369391.

9: Förster JG. Short-acting spinal anesthesia in the ambulatory setting. Curr Opin Anaesthesiol. 2014 Dec;27(6):597-604. doi: 10.1097/ACO.0000000000000126. Review. PubMed PMID: 25211156.

10: Buchwald P, Bodor N. Recent advances in the design and development of soft drugs. Pharmazie. 2014 Jun;69(6):403-13. Review. PubMed PMID: 24974571.

11: Smith T, Urquiola R, Oueis H, Stenger J. Comparison of articaine and lidocaine in the pediatric population. J Mich Dent Assoc. 2014 Jan;96(1):34-7. Review. PubMed PMID: 24654413.

12: Wulf H, Hampl K, Steinfeldt T. Speed spinal anesthesia revisited: new drugs and their clinical effects. Curr Opin Anaesthesiol. 2013 Oct;26(5):613-20. doi: 10.1097/ACO.0b013e3283606b71. Review. PubMed PMID: 26057879.

13: Dou L, Luo J, Yang D, Wang Y. The effectiveness of an additional lingual infiltration in the pulpal anesthesia of mandibular teeth: a systematic review. Quintessence Int. 2013 May;44(5):457-64. doi: 10.3290/j.qi.a29184. Review. PubMed PMID: 23479588.

14: Leith R, Lynch K, O'Connell AC. Articaine use in children: a review. Eur Arch Paediatr Dent. 2012 Dec;13(6):293-6. Review. PubMed PMID: 23235128.

15: Powell V. Articaine is superior to lidocaine in providing pulpal anesthesia. J Am Dent Assoc. 2012 Aug;143(8):897-8. Review. PubMed PMID: 22855904.

16: Becker DE, Reed KL. Local anesthetics: review of pharmacological considerations. Anesth Prog. 2012 Summer;59(2):90-101; quiz 102-3. doi: 10.2344/0003-3006-59.2.90. Review. PubMed PMID: 22822998; PubMed Central PMCID: PMC3403589.

17: Steenen SA, Dubois L, Saeed P, de Lange J. Ophthalmologic complications after intraoral local anesthesia: case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jun;113(6):e1-5. doi: 10.1016/j.tripleo.2011.07.032. Epub 2012 Feb 18. Review. PubMed PMID: 22677022.

18: Meechan JG. The use of the mandibular infiltration anesthetic technique in adults. J Am Dent Assoc. 2011 Sep;142 Suppl 3:19S-24S. Review. PubMed PMID: 21881058.

19: Förster JG, Rosenberg PH. Revival of old local anesthetics for spinal anesthesia in ambulatory surgery. Curr Opin Anaesthesiol. 2011 Dec;24(6):633-7. doi: 10.1097/ACO.0b013e32834aca1b. Review. PubMed PMID: 21841475.

20: Ogle OE, Mahjoubi G. Advances in local anesthesia in dentistry. Dent Clin North Am. 2011 Jul;55(3):481-99, viii. doi: 10.1016/j.cden.2011.02.007. Review. PubMed PMID: 21726685.

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