CP 99994 dihydrochloride
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MedKoo CAT#: 531750

CAS#: 145148-39-6 (HCl)

Description: CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro). CP 99994 dihydrochloride also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM).

Chemical Structure

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CP 99994 dihydrochloride
CAS# 145148-39-6 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 531750
Name: CP 99994 dihydrochloride
CAS#: 145148-39-6 (HCl)
Chemical Formula: C19H26Cl2N2O
Exact Mass: 0.00
Molecular Weight: 369.330
Elemental Analysis: C, 61.79; H, 7.10; Cl, 19.20; N, 7.59; O, 4.33

Price and Availability

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5mg USD 350 2 weeks
10mg USD 650 2 weeks
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Related CAS #: 145148-39-6 (HCl)   136982-36-0 (free base)    

Synonym: CP 99994 dihydrochloride; CP 99994 diHCl; CP 99994; CP99994; CP-99994.

IUPAC/Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride

InChi Key: WNHRFWPLRATIDT-FFUVTKDNSA-N

InChi Code: InChI=1S/C19H24N2O.2ClH/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15;;/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3;2*1H/t17-,19-;;/m0../s1

SMILES Code: COC1=CC=CC=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 369.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chapman RW, House A, Liu F, Celly C, Mei H, Hey JA. Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs. Eur J Pharmacol. 2004 Feb 6;485(1-3):329-32. PubMed PMID: 14757157.

2: Buccafusco JJ, Shuster LC. Effect of intrathecal pretreatment with the neurokinin receptor antagonist CP-99994 on the expression of naloxone-precipitated morphine withdrawal symptoms. Brain Res Bull. 1997;43(3):321-6. PubMed PMID: 9227843.

3: Lucot JB, Obach RS, McLean S, Watson JW. The effect of CP-99994 on the responses to provocative motion in the cat. Br J Pharmacol. 1997 Jan;120(1):116-20. PubMed PMID: 9117085; PubMed Central PMCID: PMC1564356.