MCI-225 hydrochloride hydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526996

CAS#: 476148-82-0 (HCl hydrate)

Description: MCI-225, also known as AA-10021; AA-10025; AA-10026; DDP-225, is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor potentially for the treatment of irritable. MCI-225 enhances attentional eye tracking in midpontine pretrigeminal preparation. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypometabolism.

Chemical Structure

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MCI-225 hydrochloride hydrate
CAS# 476148-82-0 (HCl hydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 526996
Name: MCI-225 hydrochloride hydrate
CAS#: 476148-82-0 (HCl hydrate)
Chemical Formula: C17H20ClFN4OS
Exact Mass: 0.00
Molecular Weight: 382.882
Elemental Analysis: C, 53.33; H, 5.27; Cl, 9.26; F, 4.96; N, 14.63; O, 4.18; S, 8.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 476148-82-0 (HCl hydrate)   135991-48-9(free base)   99487-26-0(HCl)  

Synonym: MCI-225 hydrochloride hydrate, MCI225; AA-10021; AA-10025; AA-10026; DDP-225; AA10021; AA10025; AA10026; DDP225.

IUPAC/Chemical Name: Thieno(2,3-d)pyrimidine, 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)-, monohydrochloride, monohydrate

InChi Key: SAURKKOJWIFYSR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17FN4S.ClH.H2O/c1-11-10-13-15(12-4-2-3-5-14(12)18)20-17(21-16(13)23-11)22-8-6-19-7-9-22;;/h2-5,10,19H,6-9H2,1H3;1H;1H2

SMILES Code: CC1=CC2=C(C3=CC=CC=C3F)N=C(N4CCNCC4)N=C2S1.[H]Cl.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 99487-25-9 (MCI-225 Free) 476148-82-0 (MCI-225 hydrochloride hydrate)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 382.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Eguchi J, Inomata Y, Saito K. The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. Pharmacol Biochem Behav. 2001 Apr;68(4):677-83. PubMed PMID: 11526964.

2: Ishigooka J. [Serotonin-noradrenaline reuptake inhibitors(SNRIs)]. Nihon Rinsho. 2001 Aug;59(8):1523-9. Review. Japanese. PubMed PMID: 11519152.

3: Wu YL, Yoshida M, Emoto H, Ishii H, Koga K, Tanaka M. Effects of acute and chronic administration of MCI-225, a new selective noradrenaline reuptake inhibitor with 5-HT3 receptor blocking action, on extracellular noradrenaline levels in the hypothalamus of stressed rats. Jpn J Pharmacol. 2000 May;83(1):31-8. PubMed PMID: 10887938.

4: MCI 225. Drugs R D. 1999 Jul;2(1):51-2. PubMed PMID: 10610283.

5: Eguchi J, Inomata Y, Yuasa T, Egawa M, Saito K. Pharmacological profile of the novel antidepressant 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno-[2,3-d]pyrimidine monohydrate hydrochloride. Arzneimittelforschung. 1997 Dec;47(12):1337-47. PubMed PMID: 9450161.

6: Eguchi J, Saitoh Y, Egawa M, Saito K, Kawamura H. MCI-225, a novel thienopyrimidine analog, enhances attentional eye tracking in midpontine pretrigeminal preparation. Pharmacol Biochem Behav. 1997 Feb;56(2):229-34. PubMed PMID: 9050079.

7: Eguchi J, Iwai K, Yuasa T, Egawa M, Komatsu T, Saito K. Effects of MCI-225 on memory and glucose utilization in basal forebrain-lesioned rats. Pharmacol Biochem Behav. 1995 Aug;51(4):935-9. PubMed PMID: 7675880.

8: Eguchi J, Yuasa T, Egawa M, Tobe A. Effects of a novel compound MCI-225 on impaired learning and memory in rats. Pharmacol Biochem Behav. 1994 Jun;48(2):345-9. PubMed PMID: 8090800.

9: Oishi R, Itoh Y, Adachi N, Saeki K. Effect of a new psychoactive compound, MCI-225, on brain monoamine metabolism in rats. Jpn J Pharmacol. 1993 Oct;63(2):261-4. PubMed PMID: 8283838.