BCX-1470

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526707

CAS#: 217099-43-9 (free

Description: BCX 1470 is a potent and selective Serine protease inhibitor. CX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. BCX 1470 may be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental.

Chemical Structure

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BCX-1470
CAS# 217099-43-9 (free
Instruction

Theoretical Analysis

MedKoo Cat#: 526707
Name: BCX-1470
CAS#: 217099-43-9 (free
Chemical Formula: C14H10N2O2S2
Exact Mass: 302.02
Molecular Weight: 302.366
Elemental Analysis: C, 55.61; H, 3.33; N, 9.26; O, 10.58; S, 21.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BCX 1470; BCX-1470; BCX 1470; BCX-1470 HCl.

IUPAC/Chemical Name: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate

InChi Key: OTGQTQBPQCRNRG-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H10N2O2S2/c15-13(16)12-6-8-3-4-9(7-11(8)20-12)18-14(17)10-2-1-5-19-10/h1-7H,(H3,15,16)

SMILES Code: O=C(C1=CC=CS1)OC2=CC=C3C=C(C(N)=N)SC3=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related: 217099-43-9 (BCX-1470 free) 217099-44-0 (BCX-1470 mesylate).

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 302.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick
JM, Babu YS, Volanakis JE. The Arthus reaction in rodents: species-specific
requirement of complement. J Immunol. 2000 Jan 1;164(1):463-8. PubMed PMID:
10605043.