MK-6892 | CAS#917910-45-3 | Niacin Receptor Agonsit

MK-6892
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525688

CAS#: 917910-45-3

Description: MK-6892 is a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals. MK-6892 displays excellent receptor activity, good PK across species, remarkably clean off-target profiles, good ancillary pharmacology, and superior therapeutic window over niacin.

Chemical Structure

MK-6892

CAS# 917910-45-3

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 525688
Name: MK-6892
CAS#: 917910-45-3
Chemical Formula: C19H22N4O5
Exact Mass: 386.16
Molecular Weight: 386.408
Elemental Analysis: C, 59.06; H, 5.74; N, 14.50; O, 20.70

Price and Availability

Size	Price	Availability
100mg	USD 1650	2 Weeks
200mg	USD 2650	2 Weeks
500mg	USD 3650	2 Weeks
1g	USD 4450	2 Weeks
2g	USD 7950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: MK6892; MK 6892; MK-6892

IUPAC/Chemical Name: 2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)-2,2-dimethylpropanamido)cyclohex-1-ene-1-carboxylic acid

InChi Key: CJHXBFSJXDUJHP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22N4O5/c1-19(2,18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8,10,24H,3-6,9H2,1-2H3,(H,21,27)(H,25,26)

SMILES Code: O=C(C1=C(NC(C(C)(C)CC2=NC(C3=NC=C(O)C=C3)=NO2)=O)CCCC1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.0	135.72

Preparing Stock Solutions

The following data is based on the product molecular weight 386.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Kim HY, Jadhav VB, Jeong DY, Park WK, Song JH, Lee S, Cho H. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38(6):1019-32. doi: 10.1007/s12272-015-0560-4. Epub 2015 Jan 20. PubMed PMID: 25599616.
2: Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53(6):2666-70. doi: 10.1021/jm100022r. PubMed PMID: 20184326.

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