UK 55444

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526526

CAS#: 97290-20-5

Description: UK 55444 is a potent (IC50 = 8 x 10(-9) M) calcium antagonist which is 40-fold selective for vascular over cardiac tissue and which has a significantly longer duration of action (greater than 3 h) than nifedipine in the anesthetized dog on intravenous administration.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-22. Prices are subject to change without notice.

UK 55444 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526526
Name: UK 55444
CAS#: 97290-20-5
Chemical Formula: C23H26Cl2N4O6
Exact Mass: 524.1229
Molecular Weight: 525.383
Elemental Analysis: C, 52.58; H, 4.99; Cl, 13.49; N, 10.66; O, 18.27


Synonym: UK 55444, UK 55444, UK 55444

IUPAC/Chemical Name: 3-ethyl 5-methyl 2-((2-(2-amino-4-oxo-4,5-dihydro-1H-imidazol-1-yl)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: PWEQUMVRHICAHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H26Cl2N4O6/c1-4-35-22(32)19-15(11-34-9-8-29-10-16(30)28-23(29)26)27-12(2)17(21(31)33-3)18(19)13-6-5-7-14(24)20(13)25/h5-7,18,27H,4,8-11H2,1-3H3,(H2,26,28,30)

SMILES Code: O=C(C1=C(COCCN(C(N)=N2)CC2=O)NC(C)=C(C(OC)=O)C1C3=CC=CC(Cl)=C3Cl)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Alker D, Campbell SF, Cross PE, Burges RA, Carter AJ, Gardiner DG. Long-acting dihydropyridine calcium antagonists. 5. Synthesis and structure-activity relationships for a series of 2-[[(N-substituted-heterocyclyl)ethoxy]methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Jun;33(6):1805-11. PubMed PMID: 2342074.