MK 410

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525649

CAS#: 40738-05-4

Description: MK 410 is an indomethacin analogue and an anti-inflammatory drug. It can induce alterations in the immune system by the suppression of plasma neutral proteinase activity.

Chemical Structure

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MK 410
CAS# 40738-05-4
Instruction

Theoretical Analysis

MedKoo Cat#: 525649
Name: MK 410
CAS#: 40738-05-4
Chemical Formula: C21H23NO3S
Exact Mass: 369.14
Molecular Weight: 369.477
Elemental Analysis: C, 68.27; H, 6.27; N, 3.79; O, 12.99; S, 8.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MK-410; MK 410; MK410

IUPAC/Chemical Name: 2-(5-methoxy-2-methyl-1-(4-(methylthio)benzyl)-1H-indol-3-yl)propanoic acid

InChi Key: QTUGRCJHUSVWGW-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23NO3S/c1-13(21(23)24)20-14(2)22(12-15-5-8-17(26-4)9-6-15)19-10-7-16(25-3)11-18(19)20/h5-11,13H,12H2,1-4H3,(H,23,24)

SMILES Code: O=C(O)C(C)C1=C(C)N(CC2=CC=C(SC)C=C2)C3=C1C=C(OC)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 369.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Van Dyke K, Peden D, Van Dyke C, Jones G, Castranova V, Ma J. Inhibition by nonsteroidal antiinflammatory drugs of luminol-dependent human-granulocyte chemiluminescence and [3H]FMLP binding. Effect of sulindac sulfide, indomethacin metabolite, and optical enantiomers (+) and (-) MK830. Inflammation. 1982 Mar;6(1):113-25. PubMed PMID: 7085041.
2: Lassmann G, Curtis J, Liermann B, Mason RP, Eling TE. ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase. Arch Biochem Biophys. 1993 Jan;300(1):132-6. PubMed PMID: 8380961.
3: Hart DA, Mannerfeldt J, Babins E. Treatment of mice with indomethacin leads to the appearance of a 125,000 dalton plasma protein with the characteristics of an acute phase reactant. J Clin Lab Immunol. 1987 Jun;23(2):83-90. PubMed PMID: 2442392.
4: Markey CM, Alward A, Weller PE, Marnett LJ. Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. J Biol Chem. 1987 May 5;262(13):6266-79. PubMed PMID: 3106353.
5: Hart DA. Indomethacin induces the suppression of plasma neutral proteinase activity in mice: possible relationship to efficacy as an anti-inflammatory drug and induction of alterations in the immune system. J Clin Lab Immunol. 1986 Aug;20(4):199-205. PubMed PMID: 3020255.
6: Sato T, Ohtani Y, Yamada Y, Saitoh S, Harada H. Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats. Br J Nutr. 2002 Apr;87(4):307-14. PubMed PMID: 12064340.