CHF-1024

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524684

CAS#: 90060-20-1

Description: CHF-1024 is a novel and selective D2-dopaminergic/alpha2-adrenoceptor receptor agonist. CHF-1024 has an antiarrhythmic effect.

Chemical Structure

img
CHF-1024
CAS# 90060-20-1
Instruction

Theoretical Analysis

MedKoo Cat#: 524684
Name: CHF-1024
CAS#: 90060-20-1
Chemical Formula: C11H16ClNO2
Exact Mass: 0.00
Molecular Weight: 229.700
Elemental Analysis: C, 57.52; H, 7.02; Cl, 15.43; N, 6.10; O, 13.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CHF-1024; CHF 1024; CHF1024; UNII-HPH2L3QA2F.

IUPAC/Chemical Name: 1,2-Naphthalenediol, 5,6,7,8-tetrahydro-6-(methylamino)-, hydrochloride

InChi Key: MIMDMPWWTWVHFK-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H15NO2.ClH/c1-12-8-3-4-9-7(6-8)2-5-10(13)11(9)14;/h2,5,8,12-14H,3-4,6H2,1H3;1H

SMILES Code: CNC1CCc2c(ccc(c2O)O)C1.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 229.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Fiordaliso F, De Angelis N, Bai A, Cuccovillo I, Salio M, Serra DM, Bianchi R, Razzetti R, Latini R, Masson S. Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats. Life Sci. 2007 Sep 1;81(12):951-9. Epub 2007 Jun 21. PubMed PMID: 17825849.

2: Berni R, Cacciani F, Zaniboni M, Savi M, Bocchi L, Lapucci S, Razzetti R, Pastore F, Musso E, Stilli D. Effects of the alpha2-adrenergic/DA2-dopaminergic agonist CHF-1024 in preventing ventricular arrhythmogenesis and myocyte electrical remodeling, in a rat model of pressure-overload cardiac hypertrophy. J Cardiovasc Pharmacol. 2006 Feb;47(2):295-302. PubMed PMID: 16495769.

3: Rossoni G, Manfredi B, Cavalca V, Razzetti R, Bongrani S, Polvani GL, Berti F. The aminotetraline derivative (+/-)-(R,S)-5,6-dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF-1024) displays cardioprotection in postischemic ventricular dysfunction of the rat heart. J Pharmacol Exp Ther. 2003 Nov;307(2):633-9. Epub 2003 Sep 15. PubMed PMID: 12975493.

4: Savolainen J, Rautio J, Razzetti R, Järvinen T. A novel D2-dopaminergic and alpha2-adrenoceptor receptor agonist induces substantial and prolonged IOP decrease in normotensive rabbits. J Pharm Pharmacol. 2003 Jun;55(6):789-94. PubMed PMID: 12841939.

5: Masson S, Chimenti S, Salio M, Torri M, Limana F, Bernasconi R, Calvillo L, Santambrogio D, Gagliano N, Arosio B, Annoni G, Razzetti R, Bongrani S, Latini R. CHF-1024, a DA2/alpha2 agonist, blunts norepinephrine excretion and cardiac fibrosis in pressure overload. Cardiovasc Drugs Ther. 2001 Mar;15(2):131-8. PubMed PMID: 11669406.

6: Masson S, Masseroli M, Fiordaliso F, Calvillo L, D'Aquila S, Bernasconi R, Garrido G, Torri M, Razzetti R, Bongrani S, Latini R. Effects of a DA2/alpha2 agonist and a beta1-blocker in combination with an ACE inhibitor on adrenergic activity and left ventricular remodeling in an experimental model of left ventricular dysfunction after coronary artery occlusion. J Cardiovasc Pharmacol. 1999 Sep;34(3):321-6. PubMed PMID: 10470987.

7: Latini R, Masson S, Jeremic G, Luvarà G, Fiordaliso F, Calvillo L, Bernasconi R, Torri M, Rondelli I, Razzetti R, Bongrani S. Comparative efficacy of a DA2/alpha2 agonist and a beta-blocker in reducing adrenergic drive and cardiac fibrosis in an experimental model of left ventricular dysfunction after coronary artery occlusion. J Cardiovasc Pharmacol. 1998 Apr;31(4):601-8. PubMed PMID: 9554811.