Cgp 12388

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524612

CAS#: 108929-47-1

Description: Cgp 12388 is a beta-adrenoceptor antagonist-derived radioligands used for cardiac PET imaging due to its high hydrophilicity and affinity to beta-adrenoceptor.

Chemical Structure

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Cgp 12388
CAS# 108929-47-1
Instruction

Theoretical Analysis

MedKoo Cat#: 524612
Name: Cgp 12388
CAS#: 108929-47-1
Chemical Formula: C13H17N3O3
Exact Mass: 263.13
Molecular Weight: 263.290
Elemental Analysis: C, 59.30; H, 6.51; N, 15.96; O, 18.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Cgp 12388; Cgp-12388; Cgp12388.

IUPAC/Chemical Name: 2H-Benzimidazol-2-one, 4-(3-(isopropylamino)-2-hydroxypropoxy)-

InChi Key: ASIYUAIZUWWHJU-SECBINFHSA-N

InChi Code: InChI=1S/C13H17N3O3/c1-8(2)14-6-9(17)7-19-11-5-3-4-10-12(11)16-13(18)15-10/h3-5,8-9,14,17H,6-7H2,1-2H3/t9-/m1/s1

SMILES Code: N=1C(N=c2c1c(ccc2)OC[C@@H](CNC(C)C)O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 263.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: van Waarde A, Maas B, Doze P, Slart RH, Frijlink HW, Vaalburg W, Elsinga PH. Positron emission tomography studies of human airways using an inhaled beta-adrenoceptor antagonist, S-11C-CGP 12388. Chest. 2005 Oct;128(4):3020-7. PubMed PMID: 16236982.

2: Doze P, Elsinga PH, van Waarde A, Pieterman RM, Pruim J, Vaalburg W, Willemsen AT. Quantification of beta-adrenoceptor density in the human heart with (S)-[11C]CGP 12388 and a tracer kinetic model. Eur J Nucl Med Mol Imaging. 2002 Mar;29(3):295-304. PubMed PMID: 12002702.

3: Elsinga PH, van Waarde A, Jaeggi KA, Schreiber G, Heldoorn M, Vaalburg W. Synthesis and evaluation of (S)-4-(3-(2'-[11C]isopropylamino)-2-hydroxypropoxy) -2H-benzimidazol -2-one ((S)-[11C]CGP 12388) and (S)-4-(3-((1'-[18F]-fluoroisopropyl)amino)-2-hydroxypropoxy) -2H- benzimidazol-2-one ((S)-[18F]fluoro-CGP 12388) for visualization of beta-adrenoceptors with positron emission tomography. J Med Chem. 1997 Nov 7;40(23):3829-35. PubMed PMID: 9371248.