Terfenadine | CAS#50679-08-8| MedKoo

Terfenadine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318806

CAS#: 50679-08-8

Description: Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia.

Chemical Structure

Terfenadine

CAS# 50679-08-8

Instruction

Theoretical Analysis

MedKoo Cat#: 318806
Name: Terfenadine
CAS#: 50679-08-8
Chemical Formula: C32H41NO2
Exact Mass: 471.31
Molecular Weight: 471.685
Elemental Analysis: C, 81.48; H, 8.76; N, 2.97; O, 6.78

Price and Availability

Size	Price	Availability	Quantity
1g	USD 150
2g	USD 250
5g	USD 450
10g	USD 650
25g	USD 950
50g	USD 1650
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: BRN 5857899; BRN5857899; BRN-5857899; Terfenadine; Seldane; Terfen

IUPAC/Chemical Name: 1-(4-(tert-butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol

InChi Key: GUGOEEXESWIERI-UHFFFAOYSA-N

InChi Code: InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3

SMILES Code: OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 471.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen C. Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humans. Drugs R D. 2007;8(5):301-14. Review. PubMed PMID: 17767395.

2: Rufke C, Nieber K. [Long QT interval. Interaction of terfenadine and itraconazole]. Med Monatsschr Pharm. 2006 Jan;29(1):22-4. Review. German. PubMed PMID: 16463550.

3: van den Anker JN, de Wildt SN. [Excessive terfenadine level due to drinking grapefruit juice]. Ned Tijdschr Geneeskd. 1997 Oct 11;141(41):1976-8. Review. Dutch. PubMed PMID: 9550749.

4: Endre L, Mezei G, Kósa L, Börzsönyi L, Cserháti E. [Multicenter studies of terfenadine-containing suspensions in children with hayfever]. Orv Hetil. 1998 Jan 4;139(1):11-5. Review. Hungarian. PubMed PMID: 9454105.

5: Ishizaki T. Strategic proposals to avoid drug interactions during drug development: a lesson from a terfenadine-related drug interaction. J Toxicol Sci. 1996 Dec;21(5):301-3. Review. PubMed PMID: 9035041.

6: Paris DG, Parente TF, Bruschetta HR, Guzman E, Niarchos AP. Torsades de pointes induced by erythromycin and terfenadine. Am J Emerg Med. 1994 Nov;12(6):636-8. Review. PubMed PMID: 7945604.

7: Kivistö KT, Neuvonen PJ, Klotz U. Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences. Clin Pharmacokinet. 1994 Jul;27(1):1-5. Review. PubMed PMID: 7955768.

8: Zhang MQ, Timmerman H. Terfenadine: a mixture of equipotent antihistamine enantiomers without a clear 'isomeric ballast'. Pharm World Sci. 1993 Oct 15;15(5):186-92. Review. PubMed PMID: 8257954.

9: Aaronson DW. Effects of terfenadine on psychomotor performance. An overview. Drug Saf. 1993 Apr;8(4):321-9. Review. PubMed PMID: 8481218.

10: Jankowski R, Wagenmann M, Baroody FM, Naclerio R. Effect of terfenadine on nasal provocation. Int Arch Allergy Immunol. 1993;101(3):311-7. Review. PubMed PMID: 8324394.

11: Masheter HC. Terfenadine. The first nonsedating antihistamine. Clin Rev Allergy. 1993 Spring;11(1):5-34. Review. PubMed PMID: 8319161.

12: Pohjola-Sintonen S. [Treatment with terfenadine and ketoconazole or itraconazole can cause torsades de pointes ventricular tachycardia]. Duodecim. 1993;109(2):164-6. Review. Finnish. PubMed PMID: 8013320.

13: Wynn RL. Erythromycin and ketoconazole (Nizoral) associated with terfenadine (Seldane)-induced ventricular arrhythmias. Gen Dent. 1993 Jan-Feb;41(1):27-9. Review. PubMed PMID: 7489857.

14: Cortese LM, Bjornson DC. Comment: the new macrolide antibiotics and terfenadine. Ann Pharmacother. 1992 Jul-Aug;26(7-8):1019. Review. PubMed PMID: 1504390.

15: Ciprandi G, Iudice A, Tosca MA, Ruffoni S, Buscaglia S, Canonica GW. Comparative effects of terfenadine and loratadine in the treatment of hay fever. J Investig Allergol Clin Immunol. 1991 Dec;1(6):368-72. Review. PubMed PMID: 1669595.

16: McTavish D, Goa KL, Ferrill M. Terfenadine. An updated review of its pharmacological properties and therapeutic efficacy. Drugs. 1990 Apr;39(4):552-74. Review. PubMed PMID: 1972050.

17: Brooks CD, Karl KJ, Francom SF. Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established. Clin Exp Allergy. 1990 Jan;20(1):21-6. Review. PubMed PMID: 2107013.

18: Carter CA, Wojciechowski NJ, Hayes JM, Skoutakis VA, Rickman LA. Terfenadine, a nonsedating antihistamine. Drug Intell Clin Pharm. 1985 Nov;19(11):812-7. Review. PubMed PMID: 2866079.

19: Sorkin EM, Heel RC. Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1985 Jan;29(1):34-56. Review. PubMed PMID: 2857636.

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