RO462005
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MedKoo CAT#: 522679

CAS#: 150725-87-4

Description: RO462005 is an endothelin receptor selective agonist.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2150 2 Weeks
1g USD 2850 2 Weeks
2g USD 4250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

RO462005, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522679
Name: RO462005
CAS#: 150725-87-4
Chemical Formula: C23H27N3O6S
Exact Mass: 473.1621
Molecular Weight: 473.544
Elemental Analysis: C, 58.34; H, 5.75; N, 8.87; O, 20.27; S, 6.77


Synonym: RO462005; RO-462005; RO 462005; Ro-46-2005; Ro 46-2005; Ro46-2005.

IUPAC/Chemical Name: 4-(tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl)benzenesulfonamide

InChi Key: ZNXOKLWCOWOECF-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H27N3O6S/c1-23(2,3)16-8-10-19(11-9-16)33(28,29)26-21-20(22(25-15-24-21)31-13-12-27)32-18-7-5-6-17(14-18)30-4/h5-11,14-15,27H,12-13H2,1-4H3,(H,24,25,26)

SMILES Code: O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC=NC(OCCO)=C2OC3=CC=CC(OC)=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Maguire JJ, Kuc RE, Davenport AP. Defining the affinity and receptor sub-type
selectivity of four classes of endothelin antagonists in clinically relevant
human cardiovascular tissues. Life Sci. 2012 Oct 15;91(13-14):681-6. doi:
10.1016/j.lfs.2012.05.008. Epub 2012 May 23. PubMed PMID: 22634326.

2: Bacon CR, Davenport AP. Endothelin receptors in human coronary artery and
aorta. Br J Pharmacol. 1996 Mar;117(5):986-92. PubMed PMID: 8851522; PubMed
Central PMCID: PMC1909397.

3: Peter MG, Davenport AP. Characterization of the endothelin receptor selective
agonist, BQ3020 and antagonists BQ123, FR139317, BQ788, 50235, Ro462005 and
bosentan in the heart. Br J Pharmacol. 1996 Feb;117(3):455-462. PubMed PMID:
8821534; PubMed Central PMCID: PMC1909322.

4: Davenport AP, Kuc RE, Hoskins SL, Karet FE, Fitzgerald F. [125I]-PD151242: a
selective ligand for endothelin ETA receptors in human kidney which localizes to
renal vasculature. Br J Pharmacol. 1994 Dec;113(4):1303-10. PubMed PMID: 7534185;
PubMed Central PMCID: PMC1510473.