WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522659

CAS#: 1194453-23-0

Description: BAY8040 is a Potent and Selective Human Neutrophil Elastase Inhibitor. BAY-8040 combines excellent potency and selectivity with a promising pharmacokinetic profile. In vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function was shown in a monocrotaline-induced rat model for pulmonary arterial hypertension.

Price and Availability




BAY8040 is not in stock, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 522659
Name: BAY8040
CAS#: 1194453-23-0
Chemical Formula: C21H16F3N5O2
Exact Mass: 427.1256
Molecular Weight: 427.3872
Elemental Analysis: C, 59.02; H, 3.77; F, 13.34; N, 16.39; O, 7.49

Synonym: BAY8040; BAY-8040; BAY 8040.

IUPAC/Chemical Name: (R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile


InChi Code: InChI=1S/C21H16F3N5O2/c1-28-11-16-17(19(30)27-28)18(13-7-5-12(10-25)6-8-13)26-20(31)29(16)15-4-2-3-14(9-15)21(22,23)24/h2-9,18H,11H2,1H3,(H,26,31)(H,27,30)/t18-/m1/s1

SMILES Code: N#CC1=CC=C([C@H](C2=C3CN(C)NC2=O)NC(N3C4=CC=CC(C(F)(F)F)=C4)=O)C=C1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: von Nussbaum F, Li VM, Meibom D, Anlauf S, Bechem M, Delbeck M, Gerisch M,
Harrenga A, Karthaus D, Lang D, Lustig K, Mittendorf J, Schäfer M, Schäfer S,
Schamberger J. Potent and Selective Human Neutrophil Elastase Inhibitors with
Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine
BAY-8040 in a Pulmonary Arterial Hypertension Rat Model. ChemMedChem. 2016
Jan;11(2):199-206. doi: 10.1002/cmdc.201500269. Epub 2015 Sep 3. PubMed PMID: