SB-332235

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522632

CAS#: 276702-15-9

Description: SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner.

Chemical Structure

SB-332235

CAS# 276702-15-9

Instruction

Theoretical Analysis

MedKoo Cat#: 522632
Name: SB-332235
CAS#: 276702-15-9
Chemical Formula: C13H10Cl3N3O4S
Exact Mass: 408.95
Molecular Weight: 410.650
Elemental Analysis: C, 38.02; H, 2.45; Cl, 25.90; N, 10.23; O, 15.58; S, 7.81

Price and Availability

Size	Price	Availability	Quantity
1g	USD -1
2g	USD -1
5g	USD -1
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: SB-332235; SB 332235; SB332235.

IUPAC/Chemical Name: 6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide

InChi Key:

InChi Code:

SMILES Code: ClC1=CC=CC(NC(NC2=C(O)C(S(=O)(N)=O)=C(Cl)C=C2)=O)=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang Y, Luo W, Stricker R, Reiser G. Protease-activated receptor-1 protects
rat astrocytes from apoptotic cell death via JNK-mediated release of the
chemokine GRO/CINC-1. J Neurochem. 2006 Aug;98(4):1046-60. Epub 2006 Jun 2.
PubMed PMID: 16749907.

2: Stevenson CS, Coote K, Webster R, Johnston H, Atherton HC, Nicholls A,
Giddings J, Sugar R, Jackson A, Press NJ, Brown Z, Butler K, Danahay H.
Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory
changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am J
Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29. PubMed
PMID: 15516486.

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