Ethambutol Hydrochloride | CAS#1070-11-7 | Antimycobacterial Agent

Ethambutol Hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317792

CAS#: 1070-11-7

Description: Ethambutol Hydrochloride is a bacteriostatic antimycobacterial drug used to treat tuberculosis. It is usually part of a wider treatment of drugs that include rifampicin, pyrazinamide, and isoniazid. Ethambutol hydrochloride is an antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect.

Chemical Structure

Ethambutol Hydrochloride

CAS# 1070-11-7

Instruction

Theoretical Analysis

MedKoo Cat#: 317792
Name: Ethambutol Hydrochloride
CAS#: 1070-11-7
Chemical Formula: C10H26Cl2N2O2
Exact Mass: 0.00
Molecular Weight: 277.230
Elemental Analysis: C, 43.32; H, 9.45; Cl, 25.58; N, 10.10; O, 11.54

Price and Availability

Size	Price	Availability
5g	USD 250	2 weeks
25g	USD 450	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Ethambutol Hydrochloride; CHEBI:4878; Ethambutol HCL; (+)-ethambutol dihydrochloride; (+)-(S,S)-ethambutol dihydrochloride; OR063209; Miambutol; Myambutol; EMB Fatol; EMB Hefa; EMB-Fatol; EMB-Hefa;

IUPAC/Chemical Name: [(2S)-1-hydroxybutan-2-yl]-[2-[[(2S)-1-hydroxybutan-2-yl]azaniumyl]ethyl]azanium;dichloride

InChi Key: AUAHHJJRFHRVPV-BZDVOYDHSA-N

InChi Code: InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1

SMILES Code: CC[C@@H](CO)[NH2+]CC[NH2+][C@@H](CC)CO.[Cl-].[Cl-]

Appearance: White to off-white crystalline powder.

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 277.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: El-Ridy MS, Yehia SA, Kassem MA, Mostafa DM, Nasr EA, Asfour MH. Niosomal
encapsulation of ethambutol hydrochloride for increasing its efficacy and safety.
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10: Yen YF, Chung MS, Hu HY, Lai YJ, Huang LY, Lin YS, Chou P, Deng CY.
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experimental design in the optimisation and robustness testing of a capillary
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15: He L, Wang X, Cui P, Jin J, Chen J, Zhang W, Zhang Y. ubiA (Rv3806c) encoding
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16: Moure R, Español M, Tudó G, Vicente E, Coll P, Gonzalez-Martin J, Mick V,
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25764095.

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Ethambutol Hydrochloride featured